BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
… of PTC, and the clinical implications of BRAFV600E mutation in the diagnosis, prognosis …
its clinical implications.In this article, we review the mechanism of BRAFV600E mutation and …

Targeting BRAF mutant metastatic colorectal cancer: clinical implications and emerging therapeutic strategies

J Tie, J Desai - Targeted oncology, 2015 - Springer
… focused on targeting BRAF as an … and clinical features of BRAF mutant colorectal cancer,
the prognostic and predictive role of BRAFV600E mutation in colorectal cancer, initial clinical

[HTML][HTML] BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications

V Angerilli, G Sabella, G Centonze, S Lonardi… - Critical Reviews in …, 2022 - Elsevier
… On these bases, BRAF mutational testing is now … are needed to further stratify patients
carrying this mutation. … -V600E BRAF mutations, which accounts for 22% of all BRAF

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
… of BRAF mutation with the clinical progression, recurrence, and treatment failure of PTC has
also been demonstrated. The BRAF mutation has … mechanisms determining BRAF mutation-…

[HTML][HTML] Clinical implications of BRAF mutation test in colorectal cancer

EN Mojarad, RK Farahani, MM Haghighi… - … and Hepatology from …, 2013 - ncbi.nlm.nih.gov
… to do clinical studies on the correlation between BRAF mutation and … BRAF should be
considered. We propose studies in CRC in Iran on the clinical impact of KRAS and BRAF mutation, …

How the BRAF V600E Mutation Defines a Distinct Subgroup of Colorectal Cancer: Molecular and Clinical Implications

CE Bond, VLJ Whitehall - Gastroenterology research and …, 2018 - Wiley Online Library
… the BRAF mutation in terms of prognostic and clinical implications, and although this
mutation occurs in varied genetic backgrounds, its presence can influence clinical practice and …

Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications

AJ De Langen, EF Smit - Therapeutic Advances in Medical …, 2017 - journals.sagepub.com
… of most non-V600E BRAF mutations is increased compared with WT BRAF receptor activity,
but some BRAF mutations are kinase-dead or have lower activity than WT BRAF [Wan et al. …

BRAF mutations in melanoma and colorectal cancer: a single oncogenic mutation with different tumour phenotypes and clinical implications

F Sclafani, G Gullo, K Sheahan, J Crown - Critical reviews in oncology …, 2013 - Elsevier
… role of BRAF mutations in melanoma and colorectal cancer, focusing on similarities and
differences of BRAF mutations with respect to frequency, demographics, risk factors, mutation-…

Mutation landscape in melanoma patients clinical implications of heterogeneity of BRAF mutations

L Heinzerling, M Baiter, S Kühnapfel, G Schuler… - British journal of …, 2013 - nature.com
… of rare V600 BRAF mutations in primary tumours and different metastases of melanoma
patients, compares different detection methods, and correlates the BRAF genotype with clinical

Clinical Implication of Hot Spot BRAF Mutation, V599E, in Papillary Thyroid Cancers

H Namba, M Nakashima, T Hayashi… - … Journal of Clinical …, 2003 - academic.oup.com
… In conclusion, our study provided clinical evidence that BRAF mutation, V599E, correlates
with advanced pathological stage in papillary thyroid cancers. The search for BRAF mutation