Microsatellite Stable Colorectal Cancers Stratified by the BRAF V600E Mutation Show Distinct Patterns of Chromosomal Instability
… BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis.
BRAF wild type cancers are typically MSS and display chromosomal instability (CIN). CIN …
BRAF wild type cancers are typically MSS and display chromosomal instability (CIN). CIN …
Chromosomal Instability in BRAF Mutant, Microsatellite Stable Colorectal Cancers
… BRAF wild type cancers are typically microsatellite stable (MSS) and instead acquire
chromosomal instability (CIN). In these cancers, CIN is associated with a poor outcome. BRAF …
chromosomal instability (CIN). In these cancers, CIN is associated with a poor outcome. BRAF …
Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
N Mitsutake, JA Knauf, S Mitsutake, C Mesa Jr, L Zhang… - Cancer research, 2005 - AACR
… We selected two lines with low basal BRAF V600E expression and robust … BRAF V600E
expression on growth of thyroid PCCL3 cells. As shown in Fig. 3B, BRAF V600E expression did …
expression on growth of thyroid PCCL3 cells. As shown in Fig. 3B, BRAF V600E expression did …
Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma
… BRAF V600E induces centrosome amplification and spindle … and chromosome instability
induced by BRAF V600E . Phosphorylation of Mps1 at residue S281 induced by BRAF V600E …
induced by BRAF V600E . Phosphorylation of Mps1 at residue S281 induced by BRAF V600E …
BRAF V600E mutant oligodendroglioma‐like tumors with chromosomal instability in adolescents and young adults
K Fukuoka, Y Mamatjan, S Ryall, M Komosa… - Brain …, 2020 - Wiley Online Library
… BRAF V600E pLGG as they had whole chromosome copy number alterations in more than
10 chromosomes, … None of these cases showed a pattern of chromosomal instability similar to …
10 chromosomes, … None of these cases showed a pattern of chromosomal instability similar to …
BRAF V600E Mutant Colorectal Cancer Subtypes Based on Gene Expression
… cohort of 218 BRAF V600E with gene expression data, we … factorization to identify gene
expression–based subgroups and … of gene expression motifs that differentiate BRAF V600E …
expression–based subgroups and … of gene expression motifs that differentiate BRAF V600E …
[HTML][HTML] … -mutated colorectal cancer exhibits distinct clinicopathological features from wild-type BRAF-expressing cancer independent of the microsatellite instability …
MH Jang, S Kim, DY Hwang, WY Kim… - Journal of Korean …, 2017 - ncbi.nlm.nih.gov
… , the incidence of the BRAF V600E mutation in the current study … chromosomal instability
(CIN) pathway, whereas BRAF mutation is known to be associated with microsatellite instability (…
(CIN) pathway, whereas BRAF mutation is known to be associated with microsatellite instability (…
… Characteristics, CpG Island Methylator Phenotype, and BRAF Mutations in Microsatellite-Stable Colorectal Cancers Without Chromosomal Instability
S Kakar, G Deng, V Sahai… - … of pathology & …, 2008 - meridian.allenpress.com
… BRAF V600E mutation analysis was done by allele-specific PCR, whereas KRAS mutations
… cancer lacking both microsatellite instability and chromosomal instability, as detailed below. …
… cancer lacking both microsatellite instability and chromosomal instability, as detailed below. …
Determinants and clinical implications of chromosomal instability in cancer
L Sansregret, B Vanhaesebroeck… - Nature reviews Clinical …, 2018 - nature.com
… defects trigger chromosomal instability. … chromosomal aberrations. Pre-mitotic defects, such
as replication stress, can generate chromosome fusions that result in dicentric chromosomes, …
as replication stress, can generate chromosome fusions that result in dicentric chromosomes, …
Distinct BRAF (V600E) and KRAS mutations in high microsatellite instability sporadic colorectal cancer in African Americans
K Kumar, H Brim, F Giardiello, DT Smoot… - Clinical Cancer …, 2009 - AACR
… Known mutations in the KRAS codons 12 and 13 and BRAF V600E oncogene were analyzed
in this study. Of 98 analyzed tumors, 7 displayed the BRAF V600E point mutation, whereas …
in this study. Of 98 analyzed tumors, 7 displayed the BRAF V600E point mutation, whereas …