… BRAF mutant microsatellite-unstable (MSI) colorectal cancers have an excellent prognosis.
BRAF wild type cancers are typically MSS and display chromosomal instability (CIN). CIN …

… BRAF wild type cancers are typically microsatellite stable (MSS) and instead acquire
chromosomal instability (CIN). In these cancers, CIN is associated with a poor outcome. BRAF …

… We selected two lines with low basal BRAF V600E expression and robust … BRAF V600E
expression on growth of thyroid PCCL3 cells. As shown in Fig. 3B, BRAF V600E expression did …

… BRAF V600E induces centrosome amplification and spindle … and chromosome instability
induced by BRAF V600E . Phosphorylation of Mps1 at residue S281 induced by BRAF V600E …

… BRAF V600E pLGG as they had whole chromosome copy number alterations in more than
10 chromosomes, … None of these cases showed a pattern of chromosomal instability similar to …

… cohort of 218 BRAF V600E with gene expression data, we … factorization to identify gene
expression–based subgroups and … of gene expression motifs that differentiate BRAF V600E …

… , the incidence of the BRAF V600E mutation in the current study … chromosomal instability
(CIN) pathway, whereas BRAF mutation is known to be associated with microsatellite instability (…

… BRAF V600E mutation analysis was done by allele-specific PCR, whereas KRAS mutations
… cancer lacking both microsatellite instability and chromosomal instability, as detailed below. …

… defects trigger chromosomal instability. … chromosomal aberrations. Pre-mitotic defects, such
as replication stress, can generate chromosome fusions that result in dicentric chromosomes, …

… Known mutations in the KRAS codons 12 and 13 and BRAF V600E oncogene were analyzed
in this study. Of 98 analyzed tumors, 7 displayed the BRAF V600E point mutation, whereas …