… defects trigger chromosomal instability. … chromosomal aberrations. Pre-mitotic defects, such
as replication stress, can generate chromosome fusions that result in dicentric chromosomes, …

… We conclude that BRAF V600E IHC is reliable for the evaluation of mutational … BRAF
V600E mutation has also been shown to be useful in distinguishing sporadic microsatellite-unstable …

… This result shows that the BRAF V600E recombinant plasmid was successfully constructed
and the BRAF V600E expression level in Nthy-ori 3-1 cells surpassed that of the original wild-…

… Instability (MSI) and chromosomal instability have been described [5] . Chromosomal
instability … Tumors with chromosomal instability have chromosomal gains and losses, with or …

… All BRAF V600E mutated cases of the MSI-H group presented with a MLH1 promoter … for
BRAF V600E mutation, and all of them were wild type. In conclusion, detection of BRAF V600E …

… This latter pathway involves the previously well-defined series of genetic aberrations such
as APC mutation and chromosomal instability and accounts for the majority of colorectal …

… We propose that the effect of BRAFV600E, elicited on mitotic impairment, triggers chromosome
breakage in the presence of a defective DNA damage response mechanism. As a result, …

… All 14 colorectal carcinomas with the BRAF V600E mutation demonstrated cytoplasmic … the
immunohistochemical BRAF V600E assay was 100%. Detection of the BRAF V600E mutation …

… -repair deficiency in sporadic microsatellite-unstable colorectal cancer. In this study, 90%
of microsatellite-unstable tumors with BRAF V600E mutations were identified by positive VE1 …

… cycle, chromosomal instability, apoptosis, drug resistance and prognosis [8, 12, 15–17]. Also
the role of the KRAS-BRAF interaction (being BRAF an effector of RAS in the RAF and PI3K …