… We suggest that the correlation between BRAF V600E and MLH1 or XPD reduced
expression may be a step of the malignant process involving XRCC2 increased activity. Another …

… Microsatellite stable sporadic colorectal cancers (CRCs) can be classified as either tumours
with chromosomal instability (CIN+) or tumours that are ‘Microsatellite and Chromosomal …

… by IHC had a BRAF V600E mutation by genetic analysis; the … for the detection of a BRAF
V600E mutant tumor was 93.7% … neoplasms harboring the BRAF V600E mutation. Difficulties in …

… The expression of BRAF V600E was observed in the … The BRAF V600E expression was
scored as percentage of … Therefore, four categories for BRAF V600E expression were assigned: …

… of BRAF V600E mutation and the presence of the CpG island methylator phenotype (CIMP)
and microsatellite instability (… protein abnormalities/MSI, BRAF V600E mutation, and KRAS …

… (i) the chromosomal instability (CIN) or aneuploidy pathway, which causes numerous changes
in chromosomal copy number and structure; (ii) the microsatellite instability (MSI pathway, …

… instability that have been identified in colon cancer are microsatellite instability and chromosome
instability. … made to identify causes of chromosomal instability in colorectal cells and to …

… the impact of BRAF V600E on proangiogenic gene expression and … (BRAF V600E ). Apart
from its proproliferation effects, BRAF V600E has also been linked to reduced expression of …

… The BRAF V600E mutation is specifically associated … instability have been defined in terms
of distinct pathways for GI and other types of cancer, and although chromosomal instability (…

… in either Msh2 KO Smad4 KO BRAF V600E/+ or Smad4 KO BRAF V600E/+ (orange arrows
… Smad4 KO BRAF V600E/+ and the only oncogenic mutation in Smad4 KO BRAF V600E/+ …