… BRAF V600E mutated PTMCs exhibited signs of higher aggressiveness than PTMCs without
the mutation. BRAF V600E … Ten of 12 BRAF V600E PTMCs had the BRAF V600E mutation …

… instability (MSI-H) sporadic CRCs, its role in microsatellite stable (MSS) tumors is debated.
The majority of MSS CRCs demonstrate chromosomal instability (CIN) … BRAF V600E mutation …

… These tumors are enriched with oncogenic BRAF V600E point mutations found in 69% of …
in MSS stages III or IV tumors was associated with shorter patient survival, BRAF V600E did not …

… Chromosomal instability (CIN) is considered as a hallmark of some cancer cells leading to
aneuploidy. CIN is a known driver of early dissemination and aggressive behaviour of CUP …

… and MAPK signaling is required to generate tetraploids, we treated BRAF V600E -expressing
cells with the BRAF V600E inhibitor vemurafenib, MEK inhibitor trametinib and ERK …

… colorectal carcinoma with BRAF V600E mutation, immunohistochemistry (IHC) with the
recently developed mouse monoclonal antibody VE1 for BRAF V600E protein has shown …

… of chromosome 7. Other groups have already shown that chromosome instability is not restricted
to chromosome 7… We show here that only two thirds of BRAF V600E melanomas have a …

… BRAF V600E mutation was significantly … BRAF V600E mutation in microsatellite-stable
cases were the only variables with an affect on survival. In conclusion, chromosomal instability …

… However, we and others have demonstrated that the presence of a BRAF V600E mutation
is an unfavorable prognostic factor in microsatellite stable (MSS) colorectal carcinomas as …

… show selectivity toward BRAF V600E–mutant cells, irrespective of PTEN or RB1 expression.
… inhibitors was corroborated in a second BRAF V600E isogenic model, as well as in a panel …