… show selectivity toward BRAF V600E–mutant cells, irrespective of PTEN or RB1 expression.
… inhibitors was corroborated in a second BRAF V600E isogenic model, as well as in a panel …

… by chromosomal instability and by microsatellite instability. Microsatellite instability is a …
Activating BRAF V600E and KRAS mutations are mutually exclusive, and in this article, we …

… It has previously been conjectured that unlike PTC, CNV and chromosomal instability may
… While the BRAFV600E mutation is associated with disease severity, 18 BRAF amplifications …

… We report here a case of MA, showing both a BRAF V600E mutation and a segmental loss …
on the basis of preserved expression and microsatellite sequence stability. Our study confirms …

… than 120 loci and the presence of the BRAF V600E mutation in CoMs using MLPA. Statistical
analysis … Despite this, we have confirmed the presence of the BRAF V600E mutation and …

… The 2 major pathways for colorectal carcinogenesis are chromosomal instability and
microsatellite instability (MSI) [23]. In the chromosomal instability pathway, CRCs often follow the …

… weak intensity or heterogenous staining, which we term “equivocal” staining in the present
… to strong intensity VE1 expression in their study carried the BRAF V600E mutation; therefore…

… BRAF V600E expression attenuated the inhibition of signaling (Fig. 4b and Supplementary
… The level of BRAF V600E expression required to confer a similar fitness increment in the …

… levels in normal tissues are very low 3 , chromosomal aberrations are observed in 70–90% …
of chromosomal instability (CIN): the occasional gain or loss of whole chromosomes during …

… In thyroid carcinoma, RNA-Seq analysis has identified that 560 genes are differentially
expressed in BRAF V600E-mutated tumors compared to BRAF wild-type tumors [70]. Notably, 51 …