Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells

P Hou, D Liu, M Xing - Endocrine-related cancer, 2011 - erc.bioscientifica.com
… were observed in the expression of ERα target genes; G6PDH expression was significantly
… However, our finding suggesting a positive correlation between p27 expression and uterine …

BRAF Mutation Testing in Colorectal Cancer

SG Sharma, ML Gulley - Archives of pathology & …, 2010 - meridian.allenpress.com
… 85% have evidence of the chromosomal instability pathway of progression.5 Distinguishing
… MLH1 expression, the presence of MLH1 promoter methylation or presence of BRAF V600E

Clinicopathological and protein characterization of BRAF‐ and K‐RAS‐mutated colorectal cancer and implications for prognosis

I Zlobec, MP Bihl, H Schwarb… - … journal of cancer, 2010 - Wiley Online Library
… associated with tumors arising from the chromosomal instability (CIN) pathway following
the … and inflammatory-associated protein expression in patients with BRAF V600E and K-RAS …

Fusion-mediated chromosomal instability promotes aneuploidy patterns that resemble human tumors

L Delespaul, C Merle, T Lesluyes, P Lagarde… - Oncogene, 2019 - nature.com
… Although preliminary, our findings provide a simple model that explains how chromosomal
instability can occur in sporadic cancers without mutations that directly affect chromosome

Spectrum of BRAF Mutations and Gene Rearrangements in Ovarian Serous Carcinoma

MH Chui, JC Chang, Y Zhang, A Zehir… - JCO Precision …, 2021 - ascopubs.org
BRAF V600E oncoprotein expression was assessed by immunohistochemistry on selected
… At the molecular level, HGSC exhibits widespread chromosomal instability with somatic …

Centrosome linker–induced tetraploid segregation errors link rhabdoid phenotypes and lethal colorectal cancers

A Remo, E Manfrin, P Parcesepe, A Ferrarini… - Molecular Cancer …, 2018 - AACR
… Interfering with CROCC expression in near-diploid BRAF V600E -mutant/MSI colon cancer
… of chromosome instability (CIN) were available, revealed that CROCC expression levels …

RNF43 mutation is associated with aggressive tumor biology along with BRAF V600E mutation in right-sided colorectal cancer

A Matsumoto, Y Shimada, M Nakano… - Oncology …, 2020 - spandidos-publications.com
… of RNF43 mutation and BRAF V600E mutation has been … invasion, and BRAF V600E mutation
were independently … , APC wild, BRAF V600E mutation, microsatellite instability-high (MSI-…

Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

D Mouradov, E Domingo, P Gibbs… - Official journal of the …, 2013 - journals.lww.com
… Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer
(CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has …

BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma

AM Costa, A Herrero, MF Fresno… - Clinical …, 2008 - Wiley Online Library
BRAF V600E and the only one that did not, BRAF V600E was restricted to the Pt. The occurrence
of BRAF V600E … Conclusion BRAF V600E ‘alone’ does not represent a marker for poor …

Oncogenic mutation BRAF V600E changes phenotypic behavior of THLE-2 liver cells through alteration of gene expression

M Śmiech, P Leszczyński, C Wardell… - International Journal of …, 2022 - mdpi.com
… In conclusion, our study demonstrates that enhanced BRAF V600E expression in hepatocytes
favors cancerous development. Therefore, further research is needed to explore the …