… In addition, we provide evidence that the tumor contained the BRAF V600E mutation, as well
as … Finally, chromosomal instability per se is an indicator of increased genetic variability and …

… : chromosomal instability (CIN), Microsatellite instability (MSI) and CpG island methylator
phenotype (CIMP) (4). CIN is the most common cause of genomic instability … the BRAF-V600E …

… About 60–80 % are associated with early APC mutations and chromosomal instability [2].
Microsatellite instability (MSI) characterizes the rest of CRCs. Majority of MSI cancers are …

… and TP53 was not significant compared to patients with RAS/BRAF V600E … BRAF V600E
mutations, as the analyses remained significant upon exclusion of 3 patients with BRAF V600E …

… The lack of CNA in MSI-H CRC is due to the established inverse relationship between
chromosomal instability and microsatellite instability. Because oncogene driver AI requires copy …

… chromosomal and MSI, and ubiquitous MAPK pathway alterations. CMS4 tumors (mesenchymal)
show chromosomal instability… Also, based on gene expression profile, the BRAF-mutant …

… (MMR; microsatellite instability and/or loss of protein expression by immunohistochemical …
with loss of MLH1 expression and in none of the tumors with loss of MSH2 expression (0/13). …

… a chromosomal instability pathway, approximately 12–15 % have deficient DNA mismatch
repair (dMMR) which is characterized in the tumor by microsatellite instability (… , BRAF V600E …

… However, it has been revealed that BRAF V600E mutations … Notably, because BRAF V600E
mutations have been found … characteristic phenomenon of the chromosomal instability (CIN) …

… a loss of p16 expression and/or presence of BRAFV600E immunostaining strongly suggests
… Finally, we noticed that the loss of p16 expression and detection of BRAFV600E expression …