[HTML][HTML] Contribution of A-to-I RNA editing, M6A RNA Methylation, and Alternative Splicing to physiological brain aging and neurodegenerative diseases

V Tassinari, P La Rosa, E Guida, A Colopi… - Mechanisms of ageing …, 2023 - Elsevier
A-to-I RNA editing process and its contribution to neurodegenerative diseases. Schematic
representation showing A-to-I RNA editing process and its implications in Amyotrophic lateral …

[HTML][HTML] A-to-I RNA editing in the rat brain is age-dependent, region-specific and sensitive to environmental stress across generations

H Zaidan, G Ramaswami, YN Golumbic, N Sher… - BMC genomics, 2018 - Springer
A-to-I RNA editing in rat brain samples, and confirm previous accounts of a developmental
increase in RNA editing … factor that alters RNA editing patterns several generations forward, …

[HTML][HTML] A-to-I RNA editing does not change with age in the healthy male rat brain

AP Holmes, SH Wood, BJ Merry, JP de Magalhaes - Biogerontology, 2013 - Springer
… , we report that A-to-I RNA editing of evolutionarily conserved targets does not decline with
age in rats. Furthermore, we identify that the gene-specific link of RNA editing to aging, which …

Age-related gene-specific changes of A-to-I mRNA editing in the human brain

A Nicholas, JP De Magalhaes, Y Kraytsberg… - Mechanisms of ageing …, 2010 - Elsevier
… In the present study, we tested whether levels of RNA editing change with age by examining
two carefully selected transcripts, GABRA3 and CYFIP2. CYFIP2 is a p53-inducible protein (…

A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues

K Larsen, KK Kristensen, J Momeni… - Biochemical and …, 2016 - Elsevier
… is subject to A-to-I RNA editing mediated by adenosine deaminases acting on RNA 1 and
2 (… of the porcine IGFBP7 gene, and determined the mRNA editing in different tissues. The …

Deciphering the functions and regulation of brain-enriched A-to-I RNA editing

JB Li, GM Church - Nature neuroscience, 2013 - nature.com
… All ADARs share double-stranded RNA (dsRNA)-binding domains and catalytic deaminase
A to I. Here we discuss recent progress and future needs for studying A-to-I RNA editing from …

[HTML][HTML] A systematic review of common and brain-disease-specific RNA editing alterations providing novel insights into neurological and neurodegenerative disease …

K Karagianni, S Pettas, G Christoforidou, E Kanata… - Biomolecules, 2022 - mdpi.com
… events were reported in different organisms, and corresponding databases (RADAR,
rigorously annotated database of A-to-I RNA editing [67], DARNED [68], and REDIportal [69] have …

ADeditome provides the genomic landscape of A-to-I RNA editing in Alzheimer's disease

S Wu, M Yang, P Kim, X Zhou - Briefings in bioinformatics, 2021 - academic.oup.com
… We detected 1676 363 editing sites in 1524 samples across nine brain regions from … A-to-I
RNA editing events in a big AD population. In this study, we detected A-to-I RNA editing

[HTML][HTML] Atlas of RNA editing events affecting protein expression in aged and Alzheimer's disease human brain tissue

Y Ma, EB Dammer, D Felsky, DM Duong… - Nature …, 2021 - nature.com
RNA editing events are the canonical A-to-I editing types, which are shown as the A-to-G
and T-to-C editing … We have identified 112,779 frequent A-to-I RNA editing events, which are …

A-to-I RNA editing and human disease

S Maas, Y Kawahara, KM Tamburro, K Nishikura - RNA biology, 2006 - Taylor & Francis
… On the other hand, multiple groups reported an increased RNA editing efficiency at the A
site in brains of depressed suicide victims.Moreover, Gurevich et al reported that E site …