… of brain neurons under experimental conditions relevant to brain aging and neurodegenerative
disorders … in influencing the neurodegenerative process in brain disorders of aging (215). …

… modulate the course of aging and affect neurodegenerative diseases. SIRTSs … of brain
pathologies. This review describes updated results on sirtuins in brain aging/neurodegeneration. …

… to studies of the neurobiology of aging provides a window on the molecular substrates of
successful brain aging and neurodegenerative disorders. Aging is associated with increased …

… blood brain barrier, among others. Increased knowledge of these aspects will permit a better
… of brain aging and neurodegenerative diseases in old age as complex disorders in which …

… and cellular mechanisms of NAD + -based neuronal resilience will lead to novel approaches
for facilitating healthy brain aging and for the treatment of a range of neurological disorders. …

… component of the aging process is genetically determined. Numerous theories of aging exist,
… have allowed a significantly greater understanding of aging and age-related disease. This …

… Normal "healthy" aging is defined as aging in the absence of disease. Many aged people
who do not manifest clinical symptoms of a given age-related disorder do exhibit disease-…

… brain vulnerable to age-related neurodegenerative disorders, particularly in persons with a
… predisposition to such disorders. Neurodegenerative disorders are increasingly common as …

… , referring to central and local mechanisms of brain aging. … function in the process of brain
aging is associated with mental … common symptoms of neurodegenerative diseases [89,90,91]. …

… Nevertheless, optimism remains that such work may lead to improvement of the brain's
vitality during normal aging, as well as treatments for neurodegenerative disorders and possible …