… In addition, genetic variation in brain CYPs, depending on … These aspects of brain CYP
expression regulation and genetic … human brain. The role of CYP‐mediated metabolism in the …

… in the brain. The reason for the lack of induction of CYP1A1 and CYP1B1 in the brain is
not known, but it might be due to the presence of silencers of these genes in the brain [36-40]. …

… levels of transcription factors between neuronal and hepatic cells lead to differentiated
expression and susceptibility to the regulation of CYP genes in the brain (brain areas) and liver. …

… functions of drug-metabolizing cytochrome P450 enzymes in … As the brain is the target of
centrally acting drugs, this review … genetics, molecular structure and metabolic capacity of brain …

… Individual differences in brain CYP metabolism, due to inducers, inhibitors or genetic variation,
… –brain interface may help to regulate the penetration of drugs and toxins into the brain [ …

… analyze P450-mediated drug metabolism in the brain without … group, which showed that
brain P450s had roles in responses … Therefore both genetic and other factors regulating the …

… genes or in NADPH:cytochrome P450 oxidoreductase (POR) can have an influence. Here we
review the recent progress on drug … impact of genetic variation in drug metabolizing P450s. …

… cytochrome P450 (CYP) enzymes in the brain is an exciting and evolving field of research.
CYPs are present and active in the brain… genetics, brain CYP2D levels can be altered by both …

… the result of the interplay of genetic and epigenetic factors with … that genetics accounts for
20% to 95% of variability in drug … is defective in genes responsible for drug metabolism. In the …

… curve with cDNA from tissues known to express genes of interest (liver for genes not
expressed in our cortex or microvessel samples and brain cortex for the others). The PCR was …