The dynamics of chromatin architecture in brain development and function

I Harabula, A Pombo - Current opinion in genetics & development, 2021 - Elsevier
… •• ], and are often associated with complex brain disorders [14 • ], evolutionary … chromatin
architecture relates with different aspects of the mammalian brain function, from development

Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders

BM Pratt, H Won - Seminars in cell & developmental biology, 2022 - Elsevier
… the three-dimensional chromatin landscape have enabled a systematic characterization of
gene regulatory architecture. In this review, we outline how chromatin architecture provides a …

Neuronal and glial 3D chromatin architecture informs the cellular etiology of brain disorders

B Hu, H Won, W Mah, RB Park, B Kassim… - Nature …, 2021 - nature.com
… We therefore compared FIREs in NeuN+ and NeuN− cells to identify how local chromatin
architecture differs among these major brain cell types. We detected 3966 and 3967 FIREs in …

Lineage specific 3D genome structure in the adult human brain and neurodevelopmental changes in the chromatin interactome

S Rahman, P Dong, P Apontes… - Nucleic acids …, 2023 - academic.oup.com
… To decipher cell type specific genome architecture, and characterize fine scale changes in
the chromatin interactome across neural development, we compared the 3D genome of the …

Chromatin and nuclear architecture in the nervous system

T Takizawa, E Meshorer - Trends in neurosciences, 2008 - cell.com
… nuclear architecture and chromatin regulation. Here we discuss the relationship between
nuclear organization and function and between chromatinchromatin regulation in higher brain

Regulation of chromatin structure during neural development

Y Kishi, Y Gotoh - Frontiers in neuroscience, 2018 - frontiersin.org
… -independent, long-range chromatin interactions during neural differentiation may therefore
account in part for the global changes in chromatin architecture associated with this process. …

An atlas of chromatin accessibility in the adult human brain

JF Fullard, ME Hauberg, J Bendl, G Egervari… - Genome …, 2018 - genome.cshlp.org
… Furthermore, differentially accessible chromatin overlaps with the genetic architecture of
neuropsychiatric traits and identifies differences in molecular pathways and biological functions. …

Changes in genome architecture and transcriptional dynamics progress independently of sensory experience during post-natal brain development

L Tan, W Ma, H Wu, Y Zheng, D Xing, R Chen, X Li… - Cell, 2021 - cell.com
architecture—are both crucial for the development of nervous systems. The dynamic interplay
between cell-type-specific gene expression, chromatin … our diploid chromatin conformation …

Chromatin remodeler CHD8 in autism and brain development

A Hoffmann, D Spengler - Journal of Clinical Medicine, 2021 - mdpi.com
… By contrast, much less is understood regarding how mutations in CHD8 underpin altered
brain function and mental disease. Studies on various model organisms have been proven …

Parallel development of chromatin patterns, neuron morphology, and connections: potential for disruption in autism

MÁ García-Cabezas, H Barbas… - Frontiers in …, 2018 - frontiersin.org
… in the rodent and primate brain. We conclude that the nuclear pattern of chromatin and the
epigenetic … Analyses of nuclear architecture and chromatin patterns of neurons, using sections …