… receptors. Because of its close structural and metabolic relationship to ATP, adenosine has
… This article will attempt to answer three questions that are central to adenosine research. …

… receptors to modulate cellular func- carboxamide adenosine > R-… review is on adenosine
and adenosine receptors, and the … thyroid, rat brain, and the bovine brain. All have been cloned …

… is a potent agonist in adenosine-sensitive cellular systems and … binding to a rat brain membrane
preparation. The data … relevant R-site adenosine receptors in rat brain. Part of the results …

… adenosine mediates many of its functions around inflammation or injury [7], we hypothesize
that signaling via adenosine receptors on … how we can exploit adenosine modulation of BBB …

… of the role of adenosine receptors in the brain, concluded that adenosine released as such
… the brain and that adenosine A 2A receptors (A 2A R) were striatal-‘specific’ receptors …

… brains of fetal rats as early as GD 14 [43] supporting the concept that functional adenosine
receptors … the role of A1ARs as modulators of cardiac and neural function [4,15,42], A1ARs are …

… closely resemble those of resident human brain endothelial cells. As our … of adenosine
receptor (AR) signaling for lymphocyte entry into the CNS, we wanted to determine if human brain …

… and functional characteristics of the expressed cDNA demonstrate that we have isolated a
human brain adenosine receptor … cloning of an A 1 adenosine receptor from human brain. …

… tions of adenosine in the brain and highlights the evidence that adenosine may function
as … Release of Adenosine in Brain Adenosine in the brain is maintained at very low levels (…

… that mediates many of the physiological effects of adenosine in the brain. The binding of
agonists to A 1 AR induces inhibition of adenylate cyclase, leading to a decrease in intracellular …