Aquaporin-4 and brain edema

MC Papadopoulos, AS Verkman - Pediatric nephrology, 2007 - Springer
AQP4 is the primary water channel found in the brain, but … on AQP4, which is much more
abundantly expressed in brain … cerebrospinal fluid (CSF) formation [4]. AQP9 protein has been …

Physiological roles of aquaporin-4 in brain

EA Nagelhus, OP Ottersen - Physiological reviews, 2013 - journals.physiology.org
function, the identification of AQP4 in brain largely advanced our insight in the realm of
pathophysiology (5, 11, 13, 163, 194). The elucidation of physiological roles of AQP4 in brain had …

[HTML][HTML] Three distinct roles of aquaporin-4 in brain function revealed by knockout mice

AS Verkman, DK Binder, O Bloch, K Auguste… - … et Biophysica Acta (BBA …, 2006 - Elsevier
… of brain in vasogenic edema. This review is focused on the role of AQP4 in brain function,
as deduced largely from phenotype analysis of transgenic mice deficient in AQP4. These mice, …

The role of aquaporin 4 in the brain

C Iacovetta, E Rudloff, R Kirby - Veterinary Clinical Pathology, 2012 - Wiley Online Library
Aquaporin 4 is anchored to the cell membrane ofastrocytes through a dystrophin (Dp) …
found in the brain.31 In perivascular and subpial astrocytic endfeet, where AQP4 expression is …

Aquaporin-4 water channel in the brain and its implication for health and disease

S Mader, L Brimberg - Cells, 2019 - mdpi.com
AQP 1, 4 and 9 are expressed in the mammalian brain [1]. Aquaporin-4 (AQP4) is the most
abundant water channel in the brain, spinal cord and optic nerve and controls brain water …

The role of aquaporin-4 in synaptic plasticity, memory and disease

JA Hubbard, JI Szu, DK Binder - Brain research bulletin, 2018 - Elsevier
Aquaporin-4 (AQP4), the principal aquaporin expressed in the central nervous system (CNS,
brain and … In this review, we summarize new and exciting studies indicating that AQP4 also …

Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrier

B Nico, A Frigeri, GP Nicchia… - Journal of cell …, 2001 - journals.biologists.com
… In this study, we have investigated the expression of aquaporin 4 during blood-brain barrier
development in the optic tectum of chick embryos and newly hatched chicks, by means of …

Aquaporin-4 in brain and spinal cord oedema

S Saadoun, MC Papadopoulos - Neuroscience, 2010 - Elsevier
AQP4 deletion aggravates brain oedema produced by brain tumour and … brain and
spinal cord oedema, concentrating on the roles of the water channel protein aquaporin-4 (AQP4

Anchoring of aquaporin-4 in brain: molecular mechanisms and implications for the physiology and pathophysiology of water transport

M Amiry-Moghaddam, DS Frydenlund, OP Ottersen - Neuroscience, 2004 - Elsevier
… anchoring of AQP4 at brain–blood and brain–… functional role of AQP4 in the brain. Notably,
we will review data obtained in mice that are depleted of AQP4 at the brain–blood and brain–…

The role of aquaporin-4 in cerebral water transport and edema

O Bloch, GT Manley - Neurosurgical focus, 2007 - thejns.org
… We measured ICP and brain water content in wild-type and AQP4-deficient mice receiving a
… a functional role for AQP4 in water transport across astrocyte membranes. Aquaporin-4 has …