Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets

K Thapa, H Khan, TG Singh, A Kaur - Journal of Molecular Neuroscience, 2021 - Springer
… The current review gives a brief outline of the pathophysiological mechanism of TBI and
various biochemical pathways involved in brain injury, pharmacological treatment approaches, …

The neuroprotective potential of phytochemicals in traumatic brain injury: mechanistic insights and pharmacological implications

GM Hasan, S Anwar, A Shamsi, SS Sohal… - Frontiers in …, 2024 - frontiersin.org
… A traumatic brain injury (TBI) is an injury that takes place when an external force inflicts harm
upon the brain. This force can arise from various situations, including falls, accidents, sports-…

Dualistic roles and mechanistic insights of macrophage migration inhibitory factor in brain injury and neurodegenerative diseases

W Xuan, W Xie, F Li, D Huang, Z Zhu… - Journal of Cerebral …, 2023 - journals.sagepub.com
… In this review, we highlight the novel findings of MIF mechanistic insights in immune cells
participating in acute and chronic brain disorders, which may shed light on MIF as a …

Hypoxic-ischemic brain injury: advancements in the understanding of mechanisms and potential avenues for therapy

K Biagas - Current Opinion in Pediatrics, 1999 - journals.lww.com
… , the results should be examined for their mechanistic insights. Models of focal ischemia
produce two areas of injury—the core of injury and the penumbra. The partially ischemic …

Recovery after brain injury: mechanisms and principles

RJ Nudo - Frontiers in human neuroscience, 2013 - frontiersin.org
… recovery from neurological injury. It is now generally accepted that acquired brain injuries,
such … The proposed mechanism for this use-dependent potentiation of the injury is that NMDA …

Mechanistic insight on autophagy modulated molecular pathways in cerebral ischemic injury: from preclinical to clinical perspective

P Kalra, H Khan, A Kaur, TG Singh - Neurochemical Research, 2022 - Springer
… Cerebral ischemia is one of the most devastating brain injuries and a primary cause of …
clinical levels, options for stroke-related brain injury are still limited. Several evidence suggests …

Developmental brain injury and social determinants of health: opportunities to combine preclinical models for mechanistic insights into recovery

D Guez-Barber, AJ Eisch, AG Cristancho - Developmental …, 2023 - karger.com
… studies combining environmental manipulations with developmental brain injury, and (4) …
brain injury. We believe that future mechanistic studies combining developmental brain injury

Traumatic brain injury and the neuronal microenvironment: a potential role for neuropathological mechanotransduction

MA Hemphill, S Dauth, CJ Yu, BE Dabiri, KK Parker - Neuron, 2015 - cell.com
… ), suggesting that they play an important role in brain injury and remodeling after TBI. We
argue that to improve the mechanistic understanding of diffuse brain damage, it may be …

Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned …

PM Kochanek, RSB Clark, RA Ruppel… - Pediatric Critical Care …, 2000 - journals.lww.com
… Although these studies provide important mechanistic insight into developmental issues
related to cell death after TBI, they must be interpreted with the caveat that comparisons …

Inflammation following traumatic brain injury in humans: insights from data-driven and mechanistic models into survival and death

A Abboud, Q Mi, A Puccio, D Okonkwo… - Frontiers in …, 2016 - frontiersin.org
… While further studies are needed in order to validate key predictions, the present study
may point to both novel mechanistic insights and clinically translational applications. …