… The knowledge of the pathophysiology after traumatic head injury is … brain injury offers
differentiated therapeutic options. … In patients with severe brain injury and poor outcome, CO 2 -…

… animal models to replicate human pathophysiology. TBI models are used to study aspects of
… and secondary brain injury. Primary injury refers to the initial impact that causes the brain to …

… Traumatic brain injury continues to be a major … no definitive treatments for traumatic brain
injury. Goal of therapy is … In this review, the mechanisms of primary and secondary brain injury …

… well as on the underlying mechanism. This review describes the pathophysiological and
molecular basis of hypoxic ischemic brain injury, and differentiates between the mechanisms of …

… emission tomography ( 15 O PET) and brain tissue oximetry have demonstrated increased
oxygen diffusion gradients in hypoxic regions after traumatic brain injury (TBI). These data are …

… have partially clarified the knowledge of pathophysiologic mechanisms that potentially serves
as the … mechanisms of TBI can be classified as focal brain damage related to contact injury …

… treat the devastating consequences of brain injury. In models of … pathophysiological
mechanisms, including sustained injury … many of these pathophysiological mechanisms that may …

… after traumatic brain injury. However, while there are many potential mechanisms explaining
this … that both reduce pain and provide optimal overall outcomes after traumatic brain injury. …

Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality, affecting
millions annually worldwide. Although the majority of TBI patients return to premorbid …