Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 …

SJ Park, HT Kim, DH Lee, KP Kim, SW Kim, C Suh… - Lung cancer, 2012 - Elsevier
… They received either erlotinib or gefitinib once a day. Out of total 28 patients enrolled, 23 …
therapy for metastatic brain tumors during their disease course, either whole brain radiotherapy …

Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for brain metastasis in non-small cell lung cancer patients harboring either exon 19 or 21 …

K Kim, DH Lee, J Lee, C Suh, S Kim, JC Lee… - Journal of Clinical …, 2011 - ascopubs.org
… and 2 patients whole brain radiation. Conclusions: EGFR TKI were effective in NSCLC
patients with brain metastasis harboring either exon 19 or 21 mutations. Exon 19 mutations were …

[HTML][HTML] Prognostic analysis of patients with non-small cell lung cancer harboring exon 19 or 21 mutation in the epidermal growth factor gene and brain metastases

J Wang, Z Liu, Q Pang, T Zhang, X Chen, P Er, Y Wang… - BMC cancer, 2020 - Springer
… benefits for patients with NSCLC and brain metastases. The role of radiotherapy in the … of
intracranial lesions and prolonging the survival than either therapy alone. The benefits seemed …

Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer

H Li, X Zhang, J Cao, P Su, J Lian, X Song, W Yang… - Tumor Biology, 2015 - Springer
… However, in our study, treatment method contributed to statistically significant differences
in overall survival of patients with either EGFR exon 19 deletion or 21 point mutation. One of …

EGFR mutated non-small cell lung cancer patients: more prone to development of bone and brain metastases?

LEL Hendriks, EF Smit, BAH Vosse, WW Mellema… - Lung cancer, 2014 - Elsevier
… from mNSCLC diagnosis to metastatic bone disease and 1st SRE did not differ either. Post
… 3 EGFR+ patients had an exon 18 mutation and 8 had an exon 20 mutation; these patients …

[HTML][HTML] Exon 20 YVMA insertion is associated with high incidence of brain metastasis and inferior outcome of chemotherapy in advanced non-small cell lung cancer …

S Yang, Y Wang, C Zhao, X Li, Q Liu… - … lung cancer research, 2021 - ncbi.nlm.nih.gov
… incidence of baseline extrathoracic metastasis (P= 0.009), notably brain metastasis (P= …
brain metastasis (P= 0.002) compared by Gray’s test, with estimated 12-month brain metastasis

… associated with increased brain metastasis risk in non–small cell lung cancer: Comprehensive genomic profiling of 61 resected brain metastases versus primary non …

H Wang, Q Ou, D Li, T Qin, H Bao, X Hou, K Wang… - Cancer, 2019 - Wiley Online Library
… cases (in either primary lung tumors or brain metastases) are … NSCLC and matched brain
metastases are indicated by dots … (n = 25), 56% carried exon 19 deletion mutations, and L858R …

CNS Metastases in Patients With MET Exon 14–Altered Lung Cancers and Outcomes With Crizotinib

M Offin, J Luo, R Guo, JK Lyo, C Falcon… - JCO Precision …, 2020 - ascopubs.org
… the probability of developing brain metastasis in the 83 patients with MET exon 14–altered …
which are selective type Ib MET TKIs, are either approved or currently under study in the clinic…

[HTML][HTML] Frequent genetic alterations in EGFR-and HER2-driven pathways in breast cancer brain metastases

I Hohensee, K Lamszus, S Riethdorf… - The American journal of …, 2013 - Elsevier
… for developing brain metastases, represented by genetic alterations in either HER2 or EGFR/…
for mutations using either cDNA as template (covering exons 6 to 10 and exons 19 to 20) or …

[HTML][HTML] Relevance of PTEN loss in brain metastasis formation in breast cancer patients

H Wikman, K Lamszus, N Detels, L Uslar… - Breast Cancer …, 2012 - Springer
… In addition, 10 samples were used to sequence exons 3 and 5 for mutations. … exon 4. In
the second tumor, both alleles were mutated, resulting in one product with a deletion of exons 4 …