Pathogenesis of hepatic encephalopathy

D Häussinger, F Schliess… - … of Gastroenterology and …, 2002 - Wiley Online Library
brain osmolytes after portacaval anastomosis in the rat: implications for ammonia-induced
brain … gold standard for diagnosis of clinical and subclinical hepatic encephalopathy. Dig. Dis. …

Brain edema and hepatic encephalopathy

J Cordoba, AT Blei - Seminars in liver disease, 1996 - thieme-connect.com
osmolytes) in the brain, whose main role was to protect the cells from the hyperosmolar effects
of hyperglycemia. If blood glucose is rapidly corrected, the exit of these organic osmolytes

Osmotic shifts, cerebral edema, and neurologic deterioration in severe hepatic encephalopathy

EM Liotta, AL Romanova, BD Lizza… - Critical care …, 2018 - journals.lww.com
Hepatic encephalopathy (HE)—liver disease-related brain … to morbidity and mortality in
liver disease ( 1–4 ). During … in nonsodium osmolytes, thereby lessening cerebral edema. …

[PDF][PDF] Effects of dilutional hyponatremia on brain organic osmolytes and water content in patients with cirrhosis

T Restuccia, B Gómez‐Ansón, M Guevara… - …, 2004 - Wiley Online Library
brain organic osmolytes and brain water content in cirrhosis. … The remarkable changes
in brain organic osmolytes may … link between hyponatremia and hepatic encephalopathy. …

[PDF][PDF] Plasmatic osmolality and hepatic encephalopathy: A new player on the field?

N Weiss, C Rose - Liver international, 2020 - papyrus.bib.umontreal.ca
Cerebral oedema is a result of brain hypertonicity and increasing non-permeable
molecules … of energy metabolism in overt hepatic encephalopathy. J Hepatol. 2016;65:1120-1130. …

Glucose-derived osmolytes and energy impairment in brain edema accompanying liver failure: the role of glutamine reevaluated

J Albrecht - Gastroenterology, 2003 - gastrojournal.org
… In ammonium acetate-infused rats, advancement of HE from a pre-coma stage to coma
correlated with increased brain ammonia under conditions when glutamine synthesis was …

Organic osmolytes in hyponatremia and ammonia toxicity

J Heins, C Zwingmann - Metabolic brain disease, 2010 - Springer
… the pathogenesis of hepatic encephalopathy and hyponatremia. … The role of brain glutamine
and organic osmolytes in … The observations that the decrease of brain organic osmolytes in …

Osmotic and oxidative/nitrosative stress in ammonia toxicity and hepatic encephalopathy

B Görg, F Schliess, D Häussinger - Archives of biochemistry and biophysics, 2013 - Elsevier
… Here, increased brain glutamine levels are accompanied by decreased brain myo-inositol
and taurine levels but, importantly, the overall content of the brain osmolytes determined in …

[HTML][HTML] Brain edema in acute liver failure. A window to the pathogenesis of hepatic encephalopathy

J Vaquero, C Chung, AT Blei - Annals of hepatology, 2003 - Elsevier
… the levels of brain organic osmolytes. Infusion of ammonia … osmolytes in both normonatremic
and hyponatremic rats. Importantly, infusion of ammonia resulted in a higher degree of brain

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia

C Zwingmann, N Chatauret, C Rose, D Leibfritz… - Brain research, 2004 - Elsevier
… effects of ALF due to hepatic devascularization on the concentrations of brain glutamine
and other osmolytes in relation to the severity of encephalopathy and brain edema. In addition, …