… women with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We …
The lifetime risk of breast cancer among female mutation carriers was 82%, similar to risks …

… of hereditary forms of both breast and ovarian cancer. The overall prevalence of BRCA1/2
mutations is … to vary within families with the same BRCA1/2 mutation. This suggests there is no …

… Second, does loss of BRCA1 or BRCA2 expression play a role in … with inherited mutations
in these genes? In this review, we present a model that may explain these paradoxes of BRCA …

… The remaining six BRCA1 genomic alterations were previously … the 25 BRCA2 mutations
identified was a large genomic deletion of exons 19–20. The prevalence of BRCA1/2 mutations …

… of BRCA1 and BRCA2 mutations for colorectal cancer. Accurate knowledge of colorectal
cancer risk in BRCA1/2 … risk for colorectal cancer in BRCA1/2 mutation carriers were in high-risk …

… where founder mutations have been identified in the BRCA1 and BRCA2 genes (Tables
1 and 2). The identification of the ethnic group of families undergoing genetic counseling …

… BRCA1 and BRCA2 have each undergone multiple mu… of mutant alleles on genetic fitness.
This issue of the Journal includes analyses of inherited mutations in BRCA1 and/or BRCA2 in …

… To clarify the contribution of mutations in BRCA1 and BRCA2 to breast cancer incidence in
… with early-onset breast cancer from the UK for mutations in both BRCA1 and BRCA2 genes. …

… a hereditary predisposition to the disease. We aimed to compare the histological features
of breast cancer in women carrying mutations in the susceptibility genes BRCA1 and BRCA2 …

… factors involved will determine the inherited cancer risk. Inherited mutations in the BRCA1
or BRCA2 genes have been well-described, but mutations in ATM, CDH1, CHEK2, PALB2, …