… The aim of this review is to examine several populations where founder mutations have been
identified in the BRCA1 and BRCA2 genes (Tables 1 and 2). The identification of the ethnic …

… score prostate cancer associated with the BRCA2 founder mutation in this study, if men with
… of the true association between BRCA2 founder mutation and high Gleason score cancer. …

… The concept of the founder effect explains the reduced genetic … art in founder mutations and
some recurrent mutations that … founder mutations (variants originated from a single mutation …

… The presence of several regionally occurring BRCA1 and BRCA2 founder mutations could
… BRCA1 and BRCA2 Finnish founder mutations are responsible for 91% of the mutations in …

… mutations in these genes increase the risk of colorectal cancer. We investigated BRCA1/2
founder mutations and a … 5385insC, and BRCA2 6174delT founder mutations. Genotypes and …

… presence of nine founder mutations, 4 in BRCA1 and 5 in BRCA2, shared by … founder
mutations until today and represents the highest percentage (78%) of BRCA1 and BRCA2 mutation …

… in BRCA1 and BRCA2 testing among Ashkenazi … BRCA2 mutations among unselected
Jewish women in Ontario. We estimate the prevalence of BRCA1 and BRCA2 founder mutations …

… mutations, associated with a higher risk for ovarian cancer. In conclusion, founder mutations
in BRCA1 and BRCA2 … 3319G>T mutation is potentially linked to an increased risk of …

… ovarian cancers are associated with mutations in BRCA1 or BRCA2, there are thousands of
… Canadian ancestry and is speculated to be a founder mutation of European origin (39). Of …

… mutations in BRCA1 (185delAG and 5382insC) and BRCA2 (6174delT) that account for the
overwhelming majority of BRCA mutations in … bilateral breast cancer, 17 mutation carriers (17/…