… breast cancer and 154controls did not show any effect of this variant, … or ovarian cancer
cases, we sought to examine whether these BRCA2 variants modify breast and ovarian cancer …

… ovarian cancer risk relative to breast cancer risk, than mutations in the last third'". To see if a
similar association exists for BRCA2… proportions of breast and ovarian cancer in each family (…

… BRCA2 genes confer a high life-time risk of ovarian cancer. … cases of ovarian cancer or
breast and ovarian cancer, and in … unclassified variant and ∼11,000 BRCA2 carriers recorded. …

… (27%) containing two ovarian cancer cases only, and in 37 out … ovarian cancer cases. These
data indicate that BRCA1 and BRCA2 are the major susceptibility genes for ovarian cancer …

… Studies on ovarian cancer survival in women with a germline BRCA1 or BRCA2 pathogenic
variant have yielded conflicting results. A pooled analysis of 26 observational studies found …

… ovarian cancer (HBOC). To identify genetic risk factors for breast … ovarian cancer in a
Norwegian HBOC cohort, 101 breast and/or ovarian cancer patients negative for PVs and variants …

… to 4.7% in breast cancer. Forty out of 60 BRCA1 mutations were beyond the ovarian cancer
cluster region (OCCR), in stark contrast with 22 out of 36 BRCA2 mutations being inside the …

… This review summarizes the available data on the impact of variants on non-coding
regions of BRCA1/2 genes and their role on breast and ovarian cancer predisposition. …

… The statistical data for each BRCA1 and BRCA2 variant type are shown in Figure 3d,e, … of
601 types of variants reported in BRCA1, and 632 types reported in BRCA2 (895 variants were …

… -BRCA1/BRCA2 databases contained data from a set of 3743 families for BRCA1 and
3,650 families for BRCA2. In this report, we first analyze BRCA1/BRCA2 variants in the French …