… While the HR pathway repairs DSBs with a homology-based … in these DSB repair mechanisms
can lead to cell cycle arrest… DSB repair pathways being used by male germ cells during …

… of the different male germ cell types. DNA single-strand breaks (SSB) in male germ cells of
the … We have studied the repair of these lesions in rodent and human male germ cells using …

… of a subset of these breaks by a mechanism that leads to … mechanisms that allow germ cells
to generate recombination-… meiotic mode of double-strand break repair (DSBR). We propose …

… , expansion is limited to the post-meiotic, haploid cell and … expansion in the germ cells arises
by gap repair and depends on a … expansion must arise from repair of strand breaks. Second, …

… levels of damage or repair defects emerging with advancing age, but repair pathways in old
… germline cells of young and old flies have distinct differences in their ability to repair DSBs …

… the notion that DNA repair potential differs in different types of germ cells. It can be concluded
that DNA repair in male germ cells is generally less powerful than in somatic cell lines. On …

… and showed that it can directly or indirectly induce DNA double-strand breaks, which
have genotoxic effects on male germ cells (49). In addition, some endocrine disruptors (EDCs), …

… of DNA repair and DNA damage response pathways are operative in male germ cells and
… and male germ cell DNA integrity of defects in two different DNA repair pathways and a DNA …

… Unlike other NER proteins Ercc1 and Xpf are also involved in homologous recombination,
double-strand break repair and the repair of interstrand cross-links. Their role in …

… demonstrate that testicular germ cell extracts can detect and repair DSBs by catalyzing in
vitro recombination. Our results show the presence of HR-mediated DSB repair activity at all …