… risk of breakthrough infection among cytomegalovirus donor‐positive/recipient‐negative kidney transplant recipients receiving lower‐dose valganciclovir prophylaxis

DR Stevens, D Sawinski, E Blumberg… - Transplant Infectious …, 2015 - Wiley Online Library
… , breakthrough CMV infection while receiving prophylaxis … on LD prophylaxis developed
breakthrough CMV infection with an … 1 patient developing GCV-resistant infection. In 28 patients …

Risk factors for failure of primary (val) ganciclovir prophylaxis against cytomegalovirus infection and disease in solid organ transplant recipients

MP Khurana, IP Lodding, A Mocroft… - … Forum Infectious …, 2019 - academic.oup.com
… generally receive 90 days of valganciclovir prophylaxis after transplantation with the …
breakthrough during administration of prophylaxis. This event was defined as CMV infection

Fast breakthrough of resistant cytomegalovirus during secondary letermovir prophylaxis in a hematopoietic stem cell transplant recipient

S Jung, M Michel, T Stamminger, D Michel - BMC infectious diseases, 2019 - Springer
… Here we report a fast breakthrough of resistant cytomegalovirus during secondary LMV
prophylaxis in … Ganciclovir (GCV) and valganciclovir (valGCV) are routinely used for treating CMV …

Multicenter Analysis of Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients

M Foca, S Demirhan, FM Munoz… - … Forum Infectious …, 2024 - academic.oup.com
… at least 3 months of valganciclovir prophylaxis was planned. … , as well as other
infections in the first year posttransplant and … year after prophylaxis or during prophylaxis (breakthrough) …

The association between cytomegalovirus infection and cardiac allograft vasculopathy in the era of antiviral valganciclovir prophylaxis

D Klimczak-Tomaniak, S Roest, JJ Brugts… - …, 2020 - journals.lww.com
… Clinically relevant CMV infection, CMV infection, and CMV breakthrough infection were …
After that we performed a multivariable analysis with CMV breakthrough infection as time-…

Letermovir prophylaxis in solid organ transplant—Assessing CMV breakthrough and tacrolimus drug interaction

RJ Winstead, D Kumar, A Brown… - Transplant Infectious …, 2021 - Wiley Online Library
valganciclovir to letermovir from November 2017 to June 2020. The primary outcome was the
rate of CMV breakthrough infections while on prophylaxis. … valganciclovir, the breakthrough

Detection of ganciclovir-resistant cytomegalovirus in a prospective cohort of kidney transplant recipients receiving subtherapeutic valganciclovir prophylaxis

DD Wong, WJ van Zuylen, T Novos… - Microbiology …, 2022 - Am Soc Microbiol
breakthrough infections have been reported for a small subgroup of recipients across various
transplant settings worldwide, despite the use of valganciclovir prophylaxis (… Valganciclovir

Cytomegalovirus and Epstein‐Barr virus infections among pediatric kidney transplant recipients at a center using universal Valganciclovir Prophylaxis

G Paulsen, P Cumagun, E Mixon… - Pediatric …, 2019 - Wiley Online Library
… , which is a greater frequency of surveillance than that reported in recent publications and
could account for the higher observed rate of breakthrough infections in this study.11, 12 …

Challenges for the improvement of valganciclovir prophylaxis in solid organ transplantation and the possible role of therapeutic drug monitoring in adults

LK van Vugt, DA Hesselink… - British Journal of …, 2024 - Wiley Online Library
… has lowered the incidence of CMV infection and its … , breakthrough infections during
valganciclovir prophylaxis and late CMV infection after cessation of valganciclovir prophylaxis still …

Cytomegalovirus breakthrough and resistance during letermovir prophylaxis

GA Perchetti, MA Biernacki, H Xie, J Castor… - Bone Marrow …, 2023 - nature.com
… Patients with breakthrough CMV reactivation ≥200 IU/mL … breakthrough CMV infection
during letermovir prophylaxis. … treated preemptively with ganciclovir, valganciclovir, or foscarnet …