… Although it was originally believed that SAM acts by stimulating DNA methyltransferase
we have recently shown that SAM inhibits active demethylation in vitro and in living cells [101]. …

… imprinted genes has emerged in many cancer types. This review will briefly discuss basic
aspects of DNA methylation, recent advances in DNA methyltransferases, the role of altered …

… of breast cancer. As a consequence the role of epigenetic regulators like histone deacetylase
(… ) and DNA methyltransferase (DNMT) inhibitors as treatment for breast cancer is under …

… whether the treatment of breast cancer cells with natural … , a well characterized DNA
methyltransferase inhibitor, as … We also observed that the treatment of breast cancer cells at …

… We report that DNA methyltransferase 1 (DNMT1) expression is dysregulated in breast cancer.
… levels were elevated in breast cancer tissues and in MCF-7 breast cancer cells relative to …

… DNA methylation-induced silencing of tumor suppressors is common in cancer, reversal of
promoter DNA … (decitabine), an FDA-approved DNA methyltransferase (DNMT) inhibitor, has …

… uPA (PLAU), the breast cancer specific protein 1/… DNA hypomethylation in cancer have not
yet been clearly elucidated. There is no reduction of DNA methyltransferase activity in cancer …

… colony formation of breast cancer cells and also downregulated DNA methyltransferase 3A
(… Restoration of miR-143 expression in breast cancer cells reduces PTEN hypermethylation …

… in another ER-negative human breast cancer cell line, MDA-MB-… ER expression in the human
breast cancer cell line MCF-7. … transcript in ER-negative breast cancer cell lines, supporting …

… DNA methyltransferase activity can induce upregulation of MHC genes in human breast cancer
… data from longitudinally-collected biopsies of breast cancer patients treated with the DNA …