… Although much less frequently than BRCA1, BRCA2 also acquires promoter region
hypermethylation that is closely associated with its reduced expression in breast cancer [51] and …

… As a part of the repair mechanisms and role of SIRT1 in recruiting DNMTs, the effects of this
combination treatment was also explored on DNA methyltransferases (DNMTs) expression. …

… This study was conducted to investigate the role of four polymorphic variants of DNA
methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We …

… The two human breast cancer cell lines (MCF-7 and MDA-MB-231) used in this study were
obtained from the American Type Culture Collection (Manassas, VA). The culture of these …

… Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase
and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer …

… In mammals, so far five members of the DNA methyltransferase (DNMT) family have been …
methyltransferase activity. DNMT3L binds only very weakly to DNA, but can stimulate DNA …

… The current standard of therapy for breast cancer includes surgical resection, … on breast
cancer stem cells (BrCSC). These have been isolated from human breast tumors or breast cancer…

… Inactivation of RUNX3 expression through DNA hypermethylation has been reported in
various cancers, including those of prostate, lung and pancreas. Notably, upon reducing EZH2 …

… ) family has been associated with breast cancer metastasis. However, … DNA methyltransferase
3A (DNMT3A) were highly expressed in TNBC tissues compared with other breast cancer …

… breast cancer breast cancer breast cancer breast cancer breast cancer breast cancer breast
cancer breast cancer breast cancer breast cancer stomach cancer stomach cancer stomach …