… Because DNA methyltransferase (DNMT) inhibitors like … is interest in developing novel DNMT
inhibitors that would be more … , were assessed in two human breast cancer cell lines, MDA-…

… gene expression programming. Two contradictory changes in DNA methylation patterns are
observed in breast cancer; … DNA methylation inhibitors activate silenced tumor suppressor …

… Karpf AR, Peterson PW, Rawlins JT, Dalley BK, Yang Q, Albertsen H & Jones DA 1999
Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator …

… LSD2 in regulation of DNA methylation and gene silencing in breast cancer, and suggest
that inhibition of LSD2 in combination with DNA methyltransferase inhibition represents a novel …

… , and thus response to ICIs in breast cancer, are actively being sought. Our … DNA
methyltransferase inhibitor (DMTi), potentiated cytotoxic CD8 + T cell responses in breast cancer, …

… in breast cancer patients To test whether inhibition of DNA methyltransferase activity can
induce … of MHC genes in human breast cancer patients, we explored gene expression data from …

… Here we show that cotreatment with DNMT and HDAC inhibitors can synergistically induce
ER gene expression in ER-negative breast cancer cells. Induced expression of ER mRNA …

… gene is essential for decitabine’s inhibition of breast cancer cell growth. Reconstitution of
WT TRAF6, but not the TRAF6 C70A mutant, restored the sensitivity to decitabine treatment, …

… DNA methyltransferase inhibitors reactivate silenced tumor suppressor genes and result in
… The antitumor effect of these DNA methyltransferase inhibitors has also been explored in …

… HDAC inhibitor LBH589 down-regulates DNA methyltransferase 1 (DNMT1) protein expression
in the nucleus of human breast cancer cells. Cotreatment with the proteasomal inhibitor …