Emerging role of ferroptosis in breast cancer: New dawn for overcoming tumor progression

S Sui, S Xu, D Pang - Pharmacology & therapeutics, 2022 - Elsevier
breast cancer induce ferroptosis, and that ferroptosis inducers eliminate breast cancer cells.
Finally, we put forward prospect of using ferroptosis inducers in breast cancer therapy, and …

xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosis inducers

N Lee, AE Carlisle, A Peppers, SJ Park, MB Doshi… - Antioxidants, 2021 - mdpi.com
… for targeting the anti-ferroptotic machinery of breast cancer cells depending on their … breast
cancer and nontransformed immortalized breast epithelial cell lines, we find the breast cancer

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Y Ding, X Chen, C Liu, W Ge, Q Wang, X Hao… - Journal of hematology & …, 2021 - Springer
… with ferroptosis inducer erastin resulted in a remarkable synergistic effect on tumor treatment
[3]. … , induction of ferroptosis has become a novel potential therapeutic strategy for cancer

Recent progress in ferroptosis inducers for cancer therapy

C Liang, X Zhang, M Yang, X Dong - Advanced materials, 2019 - Wiley Online Library
cancer biology. In this report, we firstly introduce the basis of ferroptosis involved in cancer
… Next, we elaborate on ferroptosis inducers (including small molecules and nanomaterials), …

Targeting ferroptosis in breast cancer

Z Li, L Chen, C Chen, Y Zhou, D Hu, J Yang, Y Chen… - Biomarker …, 2020 - Springer
… , making it a promising therapeutic target to manage cancer. Here, we describe the current
status of ferroptosis studies in breast cancer and trace the key regulators of ferroptosis back to …

Ferroptosis Inducers Upregulate PD-L1 in Recurrent Triple-Negative Breast Cancer

C Desterke, Y Xiang, R Elhage, C Duruel, Y Chang… - Cancers, 2023 - mdpi.com
ferroptosis inducers upregulated CD274 in TNBC cells (MDA-MB-231 and HCC38). In breast
… expression levels of CD274 upregulated some ferroptosis-driver genes also associated …

A MOF-based potent ferroptosis inducer for enhanced radiotherapy of triple negative breast cancer

L Zeng, S Ding, Y Cao, C Li, B Zhao, Z Ma, J Zhou… - ACS …, 2023 - ACS Publications
… potent ferroptotic cell death, indicating the importance of integrating BSO and MPN for efficient
ferroptosis induction … In addition, the FI of BZAMH group cotreated with Fer-1 (a ferroptosis

Synthesis and in Vitro Evaluation of CAPE Derivatives as Ferroptosis Inducers in Triple Negative Breast Cancer

V Consoli, AN Fallica, NF Virzì, L Salerno… - ACS Medicinal …, 2024 - ACS Publications
… -1 inducers in those tumors sensitive to ferroptosis cell death, including breast cancer, can
… in vitro cytotoxicity toward breast cancer through a ferroptosis pathway that involves HO-1 …

Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer

SY Park, KJ Jeong, A Poire, D Zhang, YH Tsang… - Cell death & …, 2023 - nature.com
Ferroptosis inducer activity in a panel of luminal BC We assessed the activity of ferroptosis
inducers in a panel of 9 luminal BC cell lines. Erastin (xCT: SLC7A11 and SLC3A2 inhibitor) …

Vulnerability of triple-negative breast cancer to saponin Formosanin C-induced ferroptosis

HC Chen, HH Tang, WH Hsu, SY Wu, WH Cheng… - Antioxidants, 2022 - mdpi.com
… Using a ferroptosis-specific inhibitor and iron chelator, the … negative breast cancer (TNBC)
MDA-MB-231 cells to ferroptosis … potent ferroptosis inducer characterized by superior induction