… the PI3K/AKT/mTOR axis. … breast cancer, the components of the AKT signaling pathway,
the factors that activate this protein kinase B, PI3K/AKT-breast cancer mutations, PI3K/AKT/mTOR…

… pathways driving breast cancer cell growth, survival, and motility is the PI3K/AKT/mTOR
signaling … development and efficacy of different PI3K inhibitors for breast cancer treatment. …

… Multiple inhibitors of the PI3K/Akt/mTOR pathway are in preclinical development or are … of
PI3K/Akt are active in breast cancers. Everolimus is a rapamycin analog and inhibitor of mTOR, …

… inhibition can augment the benefit of endocrine therapy in ER+ breast cancer… PI3K/AKT/mTOR
pathway in driving ER+ breast tumors, and its inherent interdependence with ER signaling…

… PI3K/Akt/mTOR pathway is found in many types of cancer and thus plays a major role in breast
cancer cell proliferation and anti-cancer … activation of this pathway include: constitutively …

… As with other subtypes of breast cancer, aberrations in the PI3K/AKT/mTOR pathway are
common in TNBC. Preclinical data support the notion that these aberrations predict TNBC …

… drugs for ER+ breast cancer. This article reviews the function of the phosphoinositide 3-kinase
(PI3K)/AKT/mTOR pathway and the various classes of PI3K pathway inhibitors that have …

… dependent upon activation of the PI3K pathway, there has been … this signaling cascade.
Here we review key molecules involved with aberrant PI3K pathway activation in breast cancers …

… PI3K/Akt/mTOR pathway has been known to be frequently modified in breast cancer as well
as in other types of cancers … identified as an important target in breast cancer research. First-…

… Thus, this pathway may have a role as a potential therapeutic target, as well as prognostic
… with breast cancer. Despite the existence of selective PI3K/Akt/mTOR pathway inhibitors and …