… , and subtyping is necessary to better identify molecular-based therapies. In this … 21 breast
cancer data sets and identified 587 TNBC cases. Cluster analysis identified 6 TNBC subtypes …

… subtypes of human breast cancer. In an attempt to identify those models that most closely
reflect human disease subtypes, … 27 different GEMMs of mammary carcinomas and compared …

… mouse models (GEMMs). We define and characterize 17 distinct murine subtypes of mammary
carcinoma (… from the human subtypes), which we compare to three human breast tumor …

… and, particularly for some cancer types, standardization of the … of mouse model systems that
can be used for breast cancer re… -negative breast cancer subtypes and preclinical models for …

… breast cancer subtypes, it is evident that certain models can … on advances in modeling
breast cancer at defined stages of … shortcomings in modeling particular breast cancer subtypes. …

… to classify breast cancers by their molecular (intrinsic) subtypes, … Although not identical to
the clinical subtypes, there are … -enriched, and TN and basal cancers in terms of frequency, …

… subtypes of human breast cancer. Practical aspects and key issues involved in choosing an
animal model … and limitations of the most commonly utilized rodent models of breast cancer. …

… (TNBC), an aggressive, metastatic and recurrent breast cancer (BC) subtype, currently …
preclinical models that faithfully reproduce the clinical scenario. We describe two preclinical …

… behavior of selected mammary tissues. Overall, the many mouse models available are a
rich resource for experimental biology with phenocopies of breast cancer subtypes, and a …

… treatment strategy, other subtypes, such as triple negative breast cancers, do not. … preclinical
models, which frequently fail to mimic the nuances of patient-specific breast cancer subtypes…