Genomics in breast cancertherapeutic implications

PE Lønning, T Sørlie, AL Børresen-Dale - Nature Clinical Practice …, 2005 - nature.com
The introduction of DNA microarray techniques has had dramatic implications on cancer
research, allowing researchers to analyze expression of multiple genes in concert and relate …

Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications

A Macciò, C Madeddu - The Scientific World Journal, 2011 - Wiley Online Library
Breast cancer is the female malignant … therapeutic success, breast cancer remains a major
health issue. In the last few year the hormone therapy for estrogen-dependent breast cancer

HER2 expression beyond breast cancer: therapeutic implications for gynecologic malignancies

DP English, DM Roque, AD Santin - Molecular diagnosis & therapy, 2013 - Springer
… node-negative breast cancer patients and to be of prognostic and potential therapeutic value
in … ) has provided a distinct therapeutic advantage not only in breast cancer but also in other …

Origins of breast cancer subtypes and therapeutic implications

AH Sims, A Howell, SJ Howell, RB Clarke - Nature Clinical Practice …, 2007 - nature.com
… approaches to breast cancer classification and to suggest the origins of the breast cancer
subtypes … Clinicians can already predict response to current therapies (eg endocrine therapy, …

Therapeutic implications of cellular heterogeneity and plasticity in breast cancer

MD Brooks, ML Burness, MS Wicha - Cell stem cell, 2015 - cell.com
… Using breast cancer as a model, we discuss how an improved understanding of … therapeutic
implications of this epigenetic heterogeneity across the molecular subtypes of breast cancer

Breast cancer metastasis: mechanisms and therapeutic implications

M Park, D Kim, S Ko, A Kim, K Mo, H Yoon - International journal of …, 2022 - mdpi.com
… In terms of histone methylation, PRMT5 is a representative target for breast cancer therapy.
Several studies have reported that the inhibition of PRMT5 in breast cancer can promote a …

[HTML][HTML] HER2 overexpression and paclitaxel sensitivity in breast cancer: therapeutic implications

J Baselga, AD Seidman, PP Rosen, L Norton - Oncology-Huntington, 1997 - cgtlive.com
… agent's role in the treatment of early breast cancer; its use in high-dose intensity therapy of
breast … have significant implications for the treatment of patients with advanced breast cancer. …

[HTML][HTML] Biological subtypes of breast cancer: Prognostic and therapeutic implications

O Yersal, S Barutca - World journal of clinical oncology, 2014 - ncbi.nlm.nih.gov
… clinical behavior of cancer cells are potential targets for the development of novel therapeutics.
The present review summarizes current knowledge in breast cancer molecular biology, …

Breast cancer stem cell: the roles and therapeutic implications

F Yang, J Xu, L Tang, X Guan - Cellular and Molecular Life Sciences, 2017 - Springer
… provide potential targets for breast cancer therapy. … implications for the development of
cancer therapy. As mentioned before, BCSCs are relatively resistant to conventional therapies

Metabolic reprogramming in breast cancer and its therapeutic implications

N Gandhi, GM Das - Cells, 2019 - mdpi.com
… ERβ in breast cancer [83,88,89,90]. This apparent duality of ERβ function has very important
therapeutic implications, especially in cancers such as triple negative breast cancer that do …