The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

D Cruceriu, O Baldasici, O Balacescu… - Cellular Oncology, 2020 - Springer
… We systemize the knowledge regarding TNF-α-related therapies in breast cancer, and we
explain how TNF-α may act as both a target and a drug in different breast cancer therapeutic …

Targeting transmembrane TNF-α suppresses breast cancer growth

M Yu, X Zhou, L Niu, G Lin, J Huang, W Zhou, H Gan… - Cancer research, 2013 - AACR
… Here, we show that tmTNF-α is a surface marker for a part of breast cancers, but is absent
in normal mammary tissue. Interestingly, the results from our limited survey of patients showed …

Preclinical and clinical aspects of TNF-α and its receptors TNFR1 and TNFR2 in breast cancer

I Martínez-Reza, L Díaz, R García-Becerra - Journal of Biomedical Science, 2017 - Springer
… aspects of TNF-α and their receptors in breast cancer A great deal of preclinical research
has been undertaken in order to understand the relationship between TNF-α and breast cancer

Tumor necrosis factor α blockade: an opportunity to tackle breast cancer

MF Mercogliano, S Bruni, PV Elizalde… - Frontiers in …, 2020 - frontiersin.org
breast cancer initiation, progression, and metastasis [reviewed in (1)]. Given these facts,
understanding TNFα's pivotal role in breast cancer … with the current breast cancer treatments to …

Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells

Z Zhang, G Lin, Y Yan, X Li, Y Hu, J Wang, B Yin, Y Wu… - Oncogene, 2018 - nature.com
… -α is expressed at high levels in primary breast cancers, but not in normal breast tissue [22]. …
We speculated that tmTNF-α expressed by breast cancer cells might promote tumor …

TNF-α sensitizes chemotherapy and radiotherapy against breast cancer cells

X Wu, MY Wu, M Jiang, Q Zhi, X Bian, MD Xu… - Cancer cell …, 2017 - Springer
… In our present study, we investigate whether TNF-α could enhance the cytotoxicity of
chemotherapeutics and radiotherapy against breast cancer cells. The mechanisms involved in the …

Regulation of the inflammatory profile of stromal cells in human breast cancer: prominent roles for TNF-α and the NF-κB pathway

…, H Kahani, D Banerjee, A Ben-Baruch - Stem cell research & …, 2015 - Springer
… We recently reported that TNF-α and IL-1β were minimally expressed by normal breast … from
most breast cancer patients [41]. In such individuals, the elevated expression of TNF-α and IL…

[HTML][HTML] Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1

X Cai, C Cao, J Li, F Chen, S Zhang, B Liu, W Zhang… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… In this study, we report that TNF-α enhances the growth of breast cancer through up-…
TNF-α were positively related to those of HBXIP in clinical breast cancer tissues. Moreover, …

TNF-alpha polymorphisms and breast cancer

Y Yang, R Feng, S Bi, Y Xu - Breast cancer research and treatment, 2011 - Springer
Breast cancer (BC), the most frequent cancer in women, causes more than $7 billion
direct … As we all know, tumor necrosis factor-α (TNF-α) is the most important pro-inflammatory …

The Clinical Significance of PR, ER, NF‐κB, and TNFα in Breast Cancer

XL Zhou, W Fan, G Yang, MX Yu - Disease markers, 2014 - Wiley Online Library
… and ER with NF-κB and TNF-α in BC. In the present study, we attempt to investigate the
expression of PR, ER, NF-κB, and TNF-α in human breast cancer and the possible correlations of …