… about the extent of excretion for a particular drug into human milk is needed but may not be
… known excretion of specific medications into breast milk. More current and comprehensive …

… of the drug in breast milk by the volume of breast milk consumed daily (about 150 mL/kg). …
have a therapeutic effect on the infant if absorbed, which may be unacceptable. About 90% of …

… For this reason, its therapeutic potential has begun to be tested … , milk exosomes have
notable advantages over other drug … But also, exosomes from bovine milk are used as drug …

… of lactating women on medications, but also present an intriguing possibility of an innovative
mode of drug delivery to nursing infants who benefit from therapeutic concentrations of the …

… tives, diuretics, oral antidiabetic agents) taken in therapeutic doses pass into breast milk in
undetectable amounts, or in amounts so low as to be nontoxic to the nursling. For example, …

… The ratio of drug concentrations in breast milk to drug … if the therapeutic dose for infants is
not known). If the dose received in breast milk is less than 10 percent of the therapeutic dose, …

… If the dose received in breast milk is <10% of the therapeutic dose, or if the exposure index
is <10%, the degree of exposure to the drug in breast milk is considered clinically not relevant…

… breast and milk yield [ 231. Excretion of a high-clearance and/or highly lipidsoluble drug in
breast milk … requires close therapeutic drug monitoring if toxic levels of drugs in plasma and …

… therapeutic drug categories have been selected for review of the known literature on their
distribution into human breast milk… the distribution of related drugs into breast milk. This paper …

… drugs in human breast milk in the literature. … after drug ingestion to allow for removal of drugs
from breast milk before resumption of feeding. Subject 2 resumed nursing 3 to 5 hr after drug…