… drugs that are transferred into breast milk and evaluating the impact of transferred medications
on breast milk … Martin, Therapeutic potential of human breast milk derived exosomes, …

… Quantification of drugs in breast milk is important to raise our awareness of the potential …
outside the model assumptions for drugs with narrow therapeutic index. Because the described …

… into the breast milk based on ionization; however, breast milk concentrations were still …
plasma to be excreted into the breast milk, as only the unbound drug concentration can cross cell …

… infant tenofovir daily doses from breast milk of 4.2 μg/kg, which is 0.03% of the therapeutic
oral infant dose. However, infant plasma drug concentrations were not directly measured, and …

… We would have preferred to divide by the minimum therapeutic level for each drug, but
minimum therapeutic levels have not been defined for antidepressants other than tricyclics. …

… reaches the bloodstream and likely breast milk. Many commonly used drugs are inhibitors of
P-… in breast milk since this CYP isozyme is found in normal breast tissue (Iscan et al. 2001). …

… in fore-milk and hind-milk were 5.5 … -milk were higher than those in fore-milk in the same
mother, however, there was no significant correlation between the amount of drug in breastmilk …

… Because prednisolone binding to milk proteins ranges from only 10% to 12%,11 this would
… transfer to breast milk. Accordingly, we believe that the milk concentration of both drugs is …

… drugs are excreted in the breast milk … breast milk, and we estimate that breast-fed infants
would receive no more than 20% of the usual therapeutic dose for infants for any of these drugs. …

… drug exposure and breastfeeding, amount of breast milk consumed by the infant and the
inherent potency of the drugs… exposure via breast milk to recommended therapeutic infant doses…