… drug concentration is often used to estimate the dose of maternal drug delivered via breast
milk … useful when the concentration of drug in a mother'S plasma, but not in her milk, is known. …

… Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug
… interindividual variations in drug response, the dose–response relationship with respect to …

… These findings show that human milk enhances the solubility of clofazimine as a model
drug and may be a suitable drug delivery vehicle for infant populations requiring therapeutic …

… have been detected in milk when therapeutic doses of 600 mg. were taken orally (not
parenterally) by lactating women. Bromides, diazepam (Valium), anthraquinones (cascara, senna, …

… 1.1 HUMAN BREAST MILK Human breast milk is a biological … Lipid soluble drugs can penetrate
breast milk in higher … types belonging to 46 different therapeutic categories in this review. …

… blood levels following drug exposure through breast milk is an ideal … drug exposure to the
nursing infant via breast milk. Using an … can influence drug concentrations in breast milk will be …

… We can also calculate the fraction of drug the infant is ingesting through the breast milk in
comparison with an infant therapeutic dose for that same drug (percent of therapeutic exposure…

… drug transfer from the maternal circulation into breast milk and vice versa. For a drug to distribute
into breast milk… Doses within the usual therapeutic range are the focus of this discussion…

… The main principles of drug excretion into breast milk and … breast milk is <10% of the
therapeutic dose, or if the exposure index is <10%, the degree of exposure to the drug in breast milk …

… Because obtaining PK data is challenging during the early postpartum period and modeling
of drug passage into human breast milk has been limited, 22 we report the development of a …