[HTML][HTML] The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands

JE Mogensen, R Wimmer, JN Larsen… - Journal of Biological …, 2002 - ASBMB
Bet v 1 is a 17-kDa protein abundantly present in the pollen of the White birch tree and is
the primary cause of birch pollen allergy in humans. Its three-dimensional structure is …

Birch pollen allergy in Europe

T Biedermann, L Winther, SJ Till, P Panzner, A Knulst… - Allergy, 2019 - Wiley Online Library
… of allergen homologs to the major birch allergen Bet v 1. … major allergens of the birch
homologous group, and the broad time spectrum of the accompanying flowering seasons, the “birch

Birch pollen allergens

L Li, C Chang, K Guan - Current Protein and Peptide Science, 2022 - benthamdirect.com
… homologous allergens with birch allergens. Bet v 1 is one of the first allergens developed
using recombinant technology. Many forms of genetically modified Bet v 1 hypo-allergens have …

Proteomic analysis of the major birch allergen Bet v 1 predicts allergenicity for 15 birch species

MF Schenk, JHG Cordewener, AHP America… - Journal of …, 2011 - Elsevier
… and Asian white birch (Betula pendula and B. platyphylla) causes hay fever in humans.
The allergenic potency of other birch species is largely unknown. To identify birch trees with a …

Proteomic profiling of birch (Betula verrucosa) pollen extracts from different origins

A Erler, T Hawranek, L Krückemeier, C Asam… - …, 2011 - Wiley Online Library
… A main focus of this study was on the isoform distribution of Bet v 1, the major allergen of
birch pollen. Using a combination of intact mass determination and peptide sequencing, five …

Lipid transfer protein allergy: characterization and comparison to birch‐related food allergy

P Wolters, T Ostermann… - JDDG: Journal der …, 2022 - Wiley Online Library
… However, it is conceivable that the broad spectrum of foods leading to symptoms in our LTP
allergic patients may be influenced by the co-sensitivity to birch or other pollen in part of the …

[HTML][HTML] The molecular basis for allergen cross-reactivity: crystal structure and IgE-epitope mapping of birch pollen profilin

AA Fedorov, T Ball, NM Mahoney, R Valenta, SC Almo - Structure, 1997 - cell.com
… We report here the structure of the wide spread allergen, BPP, and directly identify the major
… profilin is responsible for the elicitation of the allergic response. Furthermore, BPP is the first …

Genetic engineering of a hypoallergenic trimer of the major birch pollen allergen, Bet v 1

S Vrtala, K Hirtenlehner, M Susani, M Akdis… - The FASEB …, 2001 - Wiley Online Library
… of the wild-type allergen. We used one of the most important environmental allergens, the
major birch pollen allergen, Bet v 1, as a model allergen. Bet v 1 is a major crossreactive plant …

Molecular characterization of Bip 1, a monoclonal antibody that modulates IgE binding to birch pollen allergen, Bet v 1.

S Laffer, L Vangelista, P Steinberger… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
allergic symptoms in Middle and Northern Europe, America, and Australia. Because almost
95% of birch pollen-allergic … with this protein (4), Bet v 1 was designated as a major allergen. …

[HTML][HTML] The history and science of the major birch pollen allergen Bet v 1

H Breiteneder, D Kraft - Biomolecules, 2023 - mdpi.com
… induced by birch pollen … allergen present in birch pollen extract, this allergen was chosen
as the target. Following the rules of allergen nomenclature laid down by the WHO/IUIS Allergen