Penetration of piperacillin-tazobactam into bronchial secretions after multiple doses to intensive care patients

F Jehl, C Muller-Serieys, V De Larminat… - Antimicrobial agents …, 1994 - Am Soc Microbiol
… occur in bronchial secretions after multiple doses. Whereas our data concerning the
penetration of tazobactam into bronchial secretions are unique so far, other data on piperacillin do …

Piperacillin/tazobactam in the treatment of lower respiratory tract infections: an open non-comparative and multicentered trial

J Sifuentes-Osornio, GM Ruíz-Palacios… - Journal of …, 1994 - Taylor & Francis
… a culture and Gram stain of respiratory secretions obtained by expectoration, endotracheal
… 48 h prior to starting piperacillintazobactam. The Gram stain of respiratory secretions should …

… study on the epidemiology of respiratory tract bacterial pathogens and their susceptibility to four injectable beta-lactam antibiotics: piperacillin, piperacillin/tazobactam …

F Varotto, GD Maria, R Azzaro, P Bellissima… - Journal of …, 2001 - Taylor & Francis
… this problem by carefully directing swabs on visible secretions in the oropharyngeal cavity. …
We found in this study that both piperacillin and piperacillin/tazobactam are more active than …

Piperacillin/tazobactam compared with ticarcillin/clavulanate in community-acquired bacterial lower respiratory tract infection

DM Shlaes, R Baughman, CT Boylen… - Journal of …, 1994 - academic.oup.com
… We attempted to examine antibiotic efficacy only in bacterial infection by requiring that a
Gram's stain of respiratory secretions was positive before patients could be entered into the study…

Piperacillin/tazobactam plus tobramycin versus ceftazidime plus tobramycin for the treatment of patients with nosocomial lower respiratory tract infection

M Joshi, J Bernstein, J Solomkin… - Journal of …, 1999 - academic.oup.com
… In this study, piperacillin/tazobactam plus tobramycin was shown to be more effective and …
of respiratory secretions were obtained before the start of treatment. Respiratory secretions

Efficacy and Safety Analysis of Piperacillin Tazobactam in Combination With High Frequency Chest Wall Oscillation in Patients With COPD Coupled With Pneumonia

QM MM, FL MM - Alternative Therapies in Health and Medicine, 2023 - search.proquest.com
… and effectively expel secretions produced by alveoli, deep small bronchi, main bronchi, and
trachea… the effectiveness and safety of piperacillin tazobactam in combination with the use of …

Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion

L Lorente, A Jiménez, MM Martín, JL Iribarren… - International journal of …, 2009 - Elsevier
… from respiratory secretions (tracheal aspirate >10 6 colony-forming units/mL) or isolation of
the same microorganism in blood and respiratory secretions. The respiratory microbiological …

Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia

E Boselli, D Breilh, T Rimmelé, C Guillaume… - Critical care …, 2008 - journals.lww.com
… Our results show great variability in piperacillin/tazobactam concentrations, with an
alveolar percentage penetration of 40–50% for piperacillin and 65–85% for tazobactam and a …

Steady-state plasma and intrapulmonary concentrations of piperacillin/tazobactam 4 g/0.5 g administered to critically ill patients with severe nosocomial pneumonia

E Boselli, D Breilh, M Cannesson, F Xuereb… - Intensive care …, 2004 - Springer
… ±1.2 µg/ml for tazobactam, respectively. The mean±… piperacillin and 2.1±1.1 µg/ml for
tazobactam, respectively, showing a mean percentage penetration of piperacillin and tazobactam

Piperacillin-tazobactam-induced fever in chronic respiratory diseases: Safe challenge test under premedication

M Ramassamy, M Murris, I Recoche, C Mailhol… - Revue Française d' …, 2022 - Elsevier
piperacillin-tazobactam-induced fever with a safe re-exposure to this antibiotic with a
premedication. This antibiotic was used to eradicate or to treat infection of PA in chronic respiratory