Quality by design (QbD) assisted fabrication of fast dissolving buccal film for clonidine hydrochloride: Exploring the quality attributes

PV Dangre, RD Phad, SJ Surana… - Advances in Polymer …, 2019 - Wiley Online Library
The present work endeavors fabrication of fast dissolving buccal film of clonidine hydrochloride
by employing quality by design (QbD) based approach. The total nine formulations were …

3D printed bilayer mucoadhesive buccal film of estradiol: Impact of design on film properties, release kinetics and predicted in vivo performance

S Abdella, F Afinjuomo, Y Song, R Upton… - International Journal of …, 2022 - Elsevier
… of estradiol buccal film using the solvent … buccal film fabrication using PAM. In the present
work, we employed a dual nozzle PAM technique to develop a bi-layered estradiol buccal film

Fibrous polymeric buccal film formulation, engineering and bio-interface assessment

K Nazari, E Kontogiannidou, RH Ahmad… - European Polymer …, 2017 - Elsevier
buccal model demonstrated sustained permeation once dosages are attached to the buccal
… formulate, encapsulate and engineer fibrous polymeric buccal films (on demand) is shown. …

Overview and future potential of buccal mucoadhesive films as drug delivery systems for biologics

M Montenegro-Nicolini, JO Morales - Aaps Pharmscitech, 2017 - Springer
films as buccal drug delivery systems. In light of the literature available, the buccal epithelium
is … HME-fabricated films have been previously described for small molecule drugs (85,86). …

Polymers used in buccal film: a review

M Hanif, M Zaman, V Chaurasiya - Designed Monomers and …, 2015 - Taylor & Francis
fabricate a drug delivery system with improved effectiveness, safety and patient compliance.
One of those delivery systems is buccal filmBuccal films can release the topical drugs with …

Fabrication of hierarchical polymeric thin films by spin coating toward production of amorphous solid dispersion for buccal drug delivery system: preparation …

M Albarahmieh, BA Alkhalidi - Journal of Pharmaceutical Sciences, 2018 - Elsevier
… to use in the context of buccal films. The model drugs used in this … , using an alternative,
such as buccal films, that avoids first-pass … for small drug amounts suitable for buccal delivery. …

[HTML][HTML] Quality by Design-Guided Systematic Development and Optimization of Mucoadhesive Buccal Films

AAA Hassan, K Kristó, YHEY Ibrahim, G Regdon Jr… - Pharmaceutics, 2023 - mdpi.com
… Mucoadhesive buccal films have found increased popularity in pharmaceutical drug … The
present study strives to develop and optimize chitosan-based mucoadhesive buccal films by …

Development of bilayer films based on shellac and esterified cellulose nanocrystals for buccal drug delivery

L Tang, B Hong, T Li, B Huang - Cellulose, 2019 - Springer
… Bilayer films were fabricated based on natural-based and biocompatible polymers such as
esterified cellulose nanocrystals (ECNCs) and shellac, aiming for use in buccal drug delivery. …

Quality by design approach for fabrication of extended-release buccal films for xerostomia employing hot-melt extrusion technology

RM Elkanayati, AY Darwesh, I Taha, H Wang… - European Journal of …, 2024 - Elsevier
… In conclusion, this study not only achieved the fabrication of extended-release buccal films
for xerostomia treatment but also showcased the effectiveness of a systematic QbD approach …

Hollow mesoporous silica nanoparticles-loaded ion-crosslinked bilayer films with excellent mechanical properties and high bioavailability for buccal delivery

S Wang, L Jiang, S Meng, C Liu, H Wang, Z Gao… - International Journal of …, 2022 - Elsevier
… Mucoadhesive buccal films (MBFs) become the most promising buccal mucosal delivery
system duo to its advantageous properties, including simple preparation technique and better …