The C. elegans model in toxicity testing

PR Hunt - Journal of Applied Toxicology, 2017 - Wiley Online Library
Caenorhabditis elegans is a small nematode that can be maintained at low cost and …
Unlike toxicity testing using cell cultures, C. elegans toxicity assays provide data from a whole …

The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans

JF Morley, HR Brignull, JJ Weyers… - Proceedings of the …, 2002 - National Acad Sciences
toxicity (15–18). Thus, whether aggregate formation is necessary in the transition leading to
diminished cellular … and cellular toxicity, we have used Caenorhabditis elegans expressing …

Toxicity Testing of Neurotoxic Pesticides in Caenorhabditis elegans

D Meyer, PL Williams - Journal of Toxicology and Environmental …, 2014 - Taylor & Francis
… pesticides at the sublethal cellular level, thereby advancing our understanding of the
mechanisms underlying toxicity induced by these chemicals. A proposed toxicity testing scheme for …

Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans

JN Meyer, CA Lord, XY Yang, EA Turner… - Aquatic toxicology, 2010 - Elsevier
… We employed the genetic power of the C. elegans model to explore mechanisms of toxicity,
and a novel … imaging to test for cellular uptake and transgenerational transfer of AgNPs in C. …

[HTML][HTML] Modeling molecular and cellular aspects of human disease using the nematode Caenorhabditis elegans

GA Silverman, CJ Luke, SR Bhatia, OS Long… - Pediatric …, 2009 - nature.com
… Interestingly, transgenes expressing different Aβ 1–42 variants show that cellular toxicity,
like those of the murine models, does not correlate with the intracellular accumulation of the dye…

Oxidative stress, intestinal damage, and cell apoptosis: Toxicity induced by fluopyram in Caenorhabditis elegans

Y Liu, W Zhang, Y Wang, H Liu, S Zhang, X Ji, K Qiao - Chemosphere, 2022 - Elsevier
… In the present study, Caenorhabditis elegans, a well-established model organism, was
used to evaluate the toxic effect of fluopyram and the possible molecular mechanisms. C. …

Metabolomics and phenotype assessment reveal cellular toxicity of triclosan in Caenorhabditis elegans

HM Kim, NP Long, SJ Yoon, HT Nguyen, SW Kwon - Chemosphere, 2019 - Elsevier
… In this study, the toxicity of TCS to Caenorhabditis elegans was evaluated using a … ,
and reproduction of C. elegans were monitored for a better interpretation of toxic effects. In …

Assessing behavioral toxicity with Caenorhabditis elegans

GL Anderson, RD Cole… - … Toxicology and Chemistry …, 2004 - Wiley Online Library
… The objectives of the current study were to evaluate acute 4-h toxicity testing with C. elegans
for a broad range of toxicants including organic pesticides, organic solvents, and heavy …

Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans

CI Nussbaum-Krammer, MF Neto… - JoVE (Journal of …, 2015 - jove.com
… To investigate non cell autonomous toxicity of the prion domain, we previously examined
neighboring tissues that do not express R2E2 by electron microscopy and found that …

A high-throughput method for assessing chemical toxicity using a Caenorhabditis elegans reproduction assay

WA Boyd, SJ McBride, JR Rice, DW Snyder… - Toxicology and applied …, 2010 - Elsevier
… The nematode Caenorhabditis elegans is an attractive alternative model because of its
well-… , cadmium also increases germ cell apoptosis and decreases germ cell proliferation in C. …