Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

G Luo, P Ducy, MD McKee, GJ Pinero, E Loyer… - Nature, 1997 - nature.com
… ; pathological calcification can occur in arteries" and cartilage" and … calcification has yet
been identified. A candidate molecule is matrix GLA protein (Mgp), a mineralbinding ECM protein

The identification of matrix Gla protein in cartilage.

JE Hale, JD Fraser, PA Price - Journal of Biological Chemistry, 1988 - Elsevier
… These growth plate specimens included the lower hypertrophic zone and must, therefore,
have contained a small amount of calcified cartilage in the form of calcified longitudinal septa (8…

Molecular mechanisms mediating vascular calcification: role of matrix Gla protein

D Proudfoot, CM Shanahan - Nephrology, 2006 - Wiley Online Library
… of calcification may trigger calcium deposition. One of these inhibitory factors, matrix Gla
protein (… MGP, originally isolated from bone, is a vitamin K-dependent protein that is also highly …

Cartilage formation and calcification in arteries of mice lacking matrix Gla protein

S El-Maadawy, MT Kaartinen, T Schinke… - Connective tissue …, 2003 - Taylor & Francis
Matrix Gla protein (MGP/Mgp) is a protein expressed predom… 1–3 months after birth due
to calcification of elastic fibers and … on cartilage formation that commonly occurs in calcified

[HTML][HTML] Matrix Gla protein (MGP) and bone morphogenetic protein-2 in aortic calcified lesions of aging rats

A Sweatt, DC Sane, SM Hutson, R Wallin - Journal of Thrombosis and …, 2003 - Elsevier
… K-dependent protein, matrix Gla protein (MGP) is a binding protein for bone morphogenetic
protein-2 (… Gla region in MGP is involved in BMP-2 binding. Recombinant BMP-2 binds to the …

The role of matrix Gla protein (MGP) in vascular calcification

G Bjørklund, E Svanberg, M Dadar… - Current medicinal …, 2020 - ingentaconnect.com
… : Matrix Gla protein (MGP) is a vitamin K-dependent protein, … a calcification-inhibitor although
the mechanism of action is still not fully understood. The modulation of tissue calcification

Matrix GLA protein is a developmental regulator of chondrocyte mineralization and, when constitutively expressed, blocks endochondral and intramembranous …

K Yagami, JY Suh, M Enomoto-Iwamoto… - The Journal of cell …, 1999 - rupress.org
Matrix GLA protein (MGP), a γ-carboxyglutamic acid (GLA)–rich, vitamin K–dependent and
apatite-binding protein, is a regulator of hypertrophic cartilage mineralization during …

Matrix Gla-protein: the calcification inhibitor in need of vitamin K

LJ Schurgers, ECM Cranenburg… - Thrombosis and …, 2008 - thieme-connect.com
… -dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and
Matrix Gla protein is involved in elastic fiber calcification in the dermis of pseudoxanthoma …

[HTML][HTML] Gla-rich protein, a new player in tissue calcification?

ML Cancela, N Conceição, V Laizé - Advances in Nutrition, 2012 - Elsevier
… Other notable features of GRP are: 1) a docking site for the γ-glutamyl carboxylase in the
propeptide; 2) a AXXF motif (proteolytic cleavage site also present in the matrix Gla protein) in …

Gla-rich protein is involved in the cross-talk between calcification and inflammation in osteoarthritis

S Cavaco, CSB Viegas, MS Rafael, A Ramos… - Cellular and molecular …, 2016 - Springer
… ], several VKDPs, such as matrix Gla protein (MGP), osteocalcin (OC), and recently Gla-rich …
in sturgeon calcified cartilage and characterized by the presence of 15 putative Gla residues …