… of gabapentin and pregabalin. (B) Structure and function of voltage-gated calcium channel
subunits are illustrated by a schematic diagram of a single calcium channel, including the four …

… by binding at calcium channel alpha 2 -delta (Ca V α 2 -δ) proteins. The Ca V nomenclature
is … 10–30min) action of gabapentin and pregabalin to decrease calcium influx and transmitter …

… of both gabapentinoid actions and the distinct roles of specific calcium channel subtypes
in … notion that the main therapeutic action of these drugs involves reducing calcium-mediated …

… Pregabalin is a specific ligand of the alpha 2 -delta (α 2 -δ) auxiliary subunit of voltage-gated
calcium channels… that the observed responses with pregabalin may result from activity at the …

… site of action for pregabalin, we also explored whether pregabalin had any effects on
excitation–contraction coupling. The dihydropyridine receptor or calcium channel CaV1.1 protein is …

… GBP was shown to reduce potassium-evoked calcium influx via voltage-gated calcium
channels in a mouse pituitary cell line that constitutively expresses GABA B receptors comprising …

… of action of pregabalin, a highly selective, high-affinity ligand of the P/Q type of voltage-gated
calcium channel (… hyperexcitability suggests that pregabalin reduces synaptic release of …

… Pregabalin's specificity (or unique mechanism of action) was inferred by measuring the
affinity of several central nervous system (CNS)-targeted therapeutic agents to the α 2 δ-1 and α …

… The path to understanding the mechanisms of gabapentin and pregabalin action in epilepsy,
anxiety and neuropathic pain therapeutics has been a long one. Over time there have been …

… calcium currents while minimizing its rundown. At the age period used in this work (postnatal
days 11 to 15), only P/Q type calcium channels … by blocking calcium channels during action …