… will describe how cancer cell metabolism may shape and modify the tumor microenvironment.
In … factors present in the tumor microenvironment, hypoxia and acidosis, reciprocally affect …

… summarize recent findings on the metabolic regulation of tumor cells by the TME. … metabolic
intratumoral heterogeneity, the contribution of cancer associated fibroblasts (CAFs) to tumor …

… [mainly cancer-associated fibroblasts (CAFs)]-tumor cell metabolic axis increases the metabolic
performance of tumor cells in addition to the cell’s autonomous metabolic pathways. We …

… on the course of cancer progression. Here, we summarize recent knowledge of tumour
metabolism and the tumour microenvironment, placing it in the context of tumour pH regulation, …

… metabolism and metabolic crosstalk, highlighting strategies that may lead to the improved
precision targeting of cancer cell metabolism (… how metabolic reprogramming in cancer cells …

… The gut microbiome produces a specific set of microbial metabolites that can be altered by
diet and ultimately affect cancer cell metabolism 148,149 . For example, dietary nicotinamide …

… for metabolism and biosynthesis. Cancer cell metabolism has been exploited as a target for
… , as a mechanism to promote cancer cell survival in the microenvironment [15]. Deep and …

… anti-tumour immunity and altered cancer cell metabolism. Extracellular lactate reduces T-cell …
extracellular pH in tumours is a mechanism whereby cancer cell metabolism can mediate …

… this metabolic rewiring in cancer cells derives from in vitro studies. Extensive research on the
… cell origin and the microenvironment are important determinants of cancer cell metabolism …

… flux analyzer (Agilent) has been crucial to the characterization of cancer cells metabolism
[81]. The Seahorse system permits the simultaneous assessment of glycolytic and oxidative …