Stable self-assembly of bovine α-lactalbumin exhibits target-specific antiproliferative activity in multiple cancer cells

S Mahanta, S Paul - ACS Applied Materials & Interfaces, 2015 - ACS Publications
… to normal cells. Therefore, in this study, we prepared self-assembled α-lactalbumin that
exhibits strong inherent antiproliferative potential in multiple cancer cells which can be used for …

[HTML][HTML] Investigation and comparison of the anti-tumor activities of lactoferrin, α-lactalbumin, and β-lactoglobulin in A549, HT29, HepG2, and MDA231-LM2 tumor …

HY Li, P Li, HG Yang, YZ Wang, GX Huang… - Journal of dairy …, 2019 - Elsevier
… models and tumor-bearing models to investigate the anti-tumor effects of LF, α-LA, and β-LG,
as well as evaluate the sensitive cancer cell line of each bioactive protein. …

Growth rates of a human colon adenocarcinoma cell line are regulated by the milk protein alpha-lactalbumin

LG Sternhagen, JC Allen - Bioactive components of human milk, 2001 - Springer
… suggest that a-lactalbumin in milk may promote health by inhibiting growth of potential
cancer cells. Further studies will identify the role of calcium in the bioactivity of a-lactalbumin. …

… of bovine αlactalbumin made lethal to tumor cells is highly dependent on oleic acid and induces killing in cancer cell lines and noncancer‐derived primary cells

CR Brinkmann, CW Heegaard, TE Petersen… - The FEBS …, 2011 - Wiley Online Library
… purposed selectivity for cancer cells over healthy cells because we find that some noncancerous
primary cells are even more sensitive than cancer cells. The cytotoxicity of different α-LA…

Cytotoxic aggregates of α-lactalbumin induced by unsaturated fatty acid induce apoptosis in tumor cells

M Zhang, F Yang Jr, F Yang, J Chen, CY Zheng… - Chemico-Biological …, 2009 - Elsevier
… fatty acids induce apoptosis of human lung cancer cell line A549, suggesting that such …
acid-dependent oligomerization and cytotoxicity of α-lactalbumin, and will be helpful in the …

α-Lactalbumin levels in human mammary tumors, sera, and mammary cell culture lines

GS Schultz, KE Ebner - Cancer Research, 1977 - AACR
… of breast cancer patients (5). a-Lactalbumin production was reported in a cell line derived …
To date, the levels of «-lactalbumin in primary breast tumors have not been measured. In …

Targeted vaccination against human α-lactalbumin for immunotherapy and primary immunoprevention of triple negative breast cancer

VK Tuohy, R Jaini, JM Johnson, MG Loya, D Wilk… - Cancers, 2016 - mdpi.com
… Three weeks after vaccination, mice were inoculated with 1 × 10 4 4T1 breast cancer cells
by subcutaneous injection in 100 µL PBS. Tumors were measured by Vernier caliper every …

Cytotoxicity of apo bovine α-lactalbumin complexed with La3+ on cancer cells supported by its high resolution crystal structure

DS Yarramala, P Prakash, DS Ranade, S Doshi… - Scientific Reports, 2019 - nature.com
… anticancer activity against breast cancer cells as compared to … B-α-LA complex is preferentially
more toxic to MCF-7 cells as … B-α-LA on HeLa (cervical cancer cells), KB cells (oral cancer

Theranostic α-lactalbumin-polymer-based nanocomposite as a drug delivery carrier for cancer therapy

B Delavari, B Bigdeli, F Mamashli… - ACS Biomaterials …, 2019 - ACS Publications
… normal cells compared to cancer cell lines. In parallel with the results of cytotoxicity assay,
α-… to the same concentrations of DOX in cancer cells. This was consistent with Yuan et al. who …

Divergent anticancer activity of free and formulated camel milk α-lactalbumin

VN Uversky, EM El-Fakharany, MM Abu-Serie… - Cancer …, 2017 - Taylor & Francis
… The OA-α-cLA complex mediated cancer cell death via selective … OA-α-cLA and α-cLA. OA
also caused unselective apoptosis-dependent cell death in both normal and cancer cells to a …