… cell death process, is central to cancer development and renders tumors refractory to cytotoxic
therapy. Bcl-2, the … validates Bcl-2-like proteins as important new targets in cancer therapy. …

… cancer cell survival. Alterations in the activity of BCL-2 family members are frequently found
in cancer cells and … Anti-apoptotic proteins of this family allow cancer cells to survive various …

… to neoplasia and development, bcl-2 gene function supports cell survival and appears to lie
… steps at which cell death programs are normally activated and are bypassed in cancer cells, …

… However, it also creates a liability in terms of neoplasia, as genes that normally suppress
or induce physiological cell death often become dysregulated in cancers, with defective cell …

… Bcl-2 and its close relatives is a major component of chemo-resistance. For example, with the
… Cancer Institute (NCI) panel of 60 diverse cancer cell lines, the expression level of Bcl-x L …

… and p53 gene products have been both linked to programmed cell death pathways. We
have analyzed several human breast cancer cell lines for the expression of bcl-2 and p53. We …

… cancer cells expressing bcl-2 results in the phosphorylation of bcl-2 and in programmed cell
death of the cancer cells … Our findings that prostate cancer cells that express bcl-2 are sen …

… The BCL-2 protein family regulates the intrinsic pathway, … links of the BCL-2 protein family
to cancer development and … development of BH3 mimetic anti-cancer drugs. We then describe …

… Here, we evaluated the contribution of Bcl-2 and other Bcl-2 family members to the cellular
response of SCLC cell lines to ABT-737 by first establishing the co-relationship of Bcl-2 family …

… Moreover, LNCaP/bcl-2 tumors grown in intact male nude mice were refractory … cells. Data
obtained in this study demonstrate that the bcl-2 oncoprotein can protect prostate cancer cells …