… For example, Raf/MEK/ERK is usually associated with proliferation and drug resistance of …
cells, while activation of the Raf/MEK/ERK cascade is suppressed in some prostate cancer cell …

… This study provided the first proof of concept for the targeted inhibition of ERK nuclear
translocation as a means to inhibit cancer cell proliferation while preserving the negative feedback …

… a single agent against 500 cancer cell lines, including many … activity as a RAF inhibitor in
cancer cells. Overall, the clinical … therapy in renal cell cancer and hepatocellular carcinoma, …

… In the present study, we have provided the evidence that activation of MEK-ERK plays a …
cancer cells. Quercetin treatment results in high and sustained activation of ERK in A549 cells. …

… PI3K/Akt/mTORC1 and Ras/MEK/ERK are 2 of the most frequently hyperactivated pathways
in cancer cells, we therefore investigated whether inhibiting these 2 pathways by mTORC1 …

… in cancer cells. These agents are widely expected to be both more specific to cancer cells
and … Thus, the Ras–ERK pathway is involved in “hiding” cancer cells from the immune system. …

… -2 cell line, a well-established model of pancreatic cancer cells, we analyzed the roles of
ERK1/2 activities in the regulation of cell … Methods: The ability of the MEK inhibitor PD98059 to …

… of EGFR by EGFR TKI could not lead to apoptosis of cancer cells 5, 9, 14. … , a MEK/ERK
inhibitor, was added to different NSCLC cell lines to investigate the drug resistance of these cell …

… patients with colorectal cancer, cancer cell acquired resistance … cancer cells with either
primary or acquired resistance to cetuximab, EGFR-independent constitutive activation of MEK …

… In this review we shall discuss why the PI3K/AKT/mTOR and Raf/MEK/ERK signaling …
in metabolism, growth, and survival of cancer cells in several human cancers, including BC. …