[HTML][HTML] Metabolic alterations in cancer cells and therapeutic implications
N Hammoudi, KBR Ahmed, C Garcia-Prieto… - … journal of cancer, 2011 - ncbi.nlm.nih.gov
… the metabolic differences between cancer and normal cells … cancer cell biology but also
provide an important basis for the … eliminate cancer cells by targeting their unique metabolism. …
provide an important basis for the … eliminate cancer cells by targeting their unique metabolism. …
The metabolic alterations of cancer cells
… cells. Here, we describe key features of the metabolic transformation of cancer cells, which
… reprogramming, and the deregulation of lipid metabolism, highlighting the notion that these …
… reprogramming, and the deregulation of lipid metabolism, highlighting the notion that these …
[HTML][HTML] Cancer cell metabolism: implications for therapeutic targets
M Jang, SS Kim, J Lee - Experimental & molecular medicine, 2013 - nature.com
… Cancer cell metabolism is characterized by an enhanced … The persistent activation of
aerobic glycolysis in cancer cells … may present a new basis for cancer treatment. Accordingly, …
aerobic glycolysis in cancer cells … may present a new basis for cancer treatment. Accordingly, …
Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells
UE Martinez-Outschoorn, Z Lin, YH Ko, A Goldberg… - Cell Cycle, 2011 - Taylor & Francis
… -stromal metabolic coupling, in which cancer cells induce … cancer-associated fibroblasts
provide recycled nutrients to epithelial cancer cells, "fueling" oxidative mitochondrial metabolism …
provide recycled nutrients to epithelial cancer cells, "fueling" oxidative mitochondrial metabolism …
Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism
I Samudio, M Fiegl, M Andreeff - Cancer research, 2009 - AACR
The precise mitochondrial alterations that underlie the increased dependence of cancer
cells on aerobic glycolysis for energy generation have remained a mystery. Recent evidence …
cells on aerobic glycolysis for energy generation have remained a mystery. Recent evidence …
[HTML][HTML] … nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical …
B Tan, DA Young, ZH Lu, T Wang, TI Meier… - Journal of Biological …, 2013 - ASBMB
… (TCA) cycle, and serine biosynthesis in cancer cells and tumor xenografts. We show for the
… as the central metabolic basis of NAMPT inhibition responsible for ATP depletion, metabolic …
… as the central metabolic basis of NAMPT inhibition responsible for ATP depletion, metabolic …
Regulation of cancer cell metabolism
RA Cairns, IS Harris, TW Mak - Nature Reviews Cancer, 2011 - nature.com
… core cellular metabolism and provide support for the three basic needs of dividing … cellular
redox status (Fig. 1). To meet these needs, cancer cells acquire alterations to the metabolism …
redox status (Fig. 1). To meet these needs, cancer cells acquire alterations to the metabolism …
[HTML][HTML] Metabolic requirements for cancer cell proliferation
MA Keibler, TM Wasylenko, JK Kelleher… - … & metabolism, 2016 - Springer
… to gain insight into the metabolic behavior of cancer cells using only minimal information …
Next, using these tabulated requirements as a basis, we perform stoichiometric analyses to …
Next, using these tabulated requirements as a basis, we perform stoichiometric analyses to …
Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape
G Rinaldi, M Rossi, SM Fendt - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
… In conclusion, identifying and understanding complex metabolic interactions is a basis for
deciphering novel metabolic vulnerabilities of cancer cells. WIREs Syst Biol Med 2018, 10:…
deciphering novel metabolic vulnerabilities of cancer cells. WIREs Syst Biol Med 2018, 10:…
The metabolic basis of kidney cancer
WM Linehan, CJ Ricketts - Seminars in cancer biology, 2013 - Elsevier
… cell that responds to low ATP levels compared to AMP levels and low nutrient levels by down
regulating cell growth, lipid and protein metabolism. … deficient kidney cancer cells and this …
regulating cell growth, lipid and protein metabolism. … deficient kidney cancer cells and this …
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