ROS stress in cancer cells and therapeutic implications

H Pelicano, D Carney, P Huang - Drug resistance updates, 2004 - Elsevier
… kill cancer cells through ROS-mediated mechanisms. This article reviews ROS stress in cancer
cells… Because cancer cells produce high levels of ROS and are under increased oxidative …

ROS homeostasis and metabolism: a dangerous liason in cancer cells

E Panieri, MM Santoro - Cell death & disease, 2016 - nature.com
… by sustained ROS production, cancer cells have developed an efficient mechanism of ROS
… Therefore, the dependency of cancer cells from their antioxidant systems represents a …

Cancer cell killing via ROS: to increase or decrease, that is the question

J Wang, J Yi - Cancer biology & therapy, 2008 - Taylor & Francis
… therapeutic approaches for cancers, including chemotherapy… cell death, therefore ROS are
also used to kill cancer cells. … that cancer cells exclusively produce more ROS than normal …

[HTML][HTML] Production and detection of reactive oxygen species (ROS) in cancers

D Wu, P Yotnda - Journal of visualized experiments: JoVE, 2011 - ncbi.nlm.nih.gov
… Detection of protein oxidation investigates the total effects of all ROS produced by the
studied cells; here the intensity of the signal obtained represents the amount of ROS produced. …

Reactive oxygen species (ROS): key components in cancer therapies

BM Sahoo, BK Banik, P Borah… - Anti-Cancer Agents in …, 2022 - ingentaconnect.com
… of ROS involved in different pathways of killing cancer cells during the development of anti-…
their effect on cancer cells by producing these reactive oxygen species during their metabolic …

hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells

IR Indran, MP Hande, S Pervaiz - Cancer research, 2011 - AACR
… not only reduces the basal cellular reactive oxygen species (ROS) levels but also inhibits
endogenous ROS production in response to stimuli that induce intracellular ROS generation. …

Understanding the mechanism of action of melatonin, which induces ROS production in cancer cells

J Florido, C Rodriguez-Santana, L Martinez-Ruiz… - Antioxidants, 2022 - mdpi.com
… This review described the possible pathways involved in ROS production by melatonin in
cancer cells. These mechanisms include, besides melatonin receptors, sirtuins and Akt …

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

D Trachootham, J Alexandre, P Huang - Nature reviews Drug discovery, 2009 - nature.com
… An increase in ROS is associated with abnormal cancer cell … elevation of ROS production
or to a decline of ROS-scavenging … Because the increase of ROS in cancer cells may play an …

Reactive oxygen species in cancer cells: live by the sword, die by the sword

PT Schumacker - Cancer cell, 2006 - cell.com
… , where mutations in mitochondrial DNA (which encodes specific subunits of the ETC)
have been linked to increases in ROS production and tumor progression in prostate cancer

ROS and energy metabolism in cancer cells: alliance for fast growth

SW Kang, S Lee, EK Lee - Archives of pharmacal research, 2015 - Springer
… NADPH oxidase and the ROS-eliminating antioxidant enzymes, both of … between ROS
and energy metabolisms in cancer cells. … production and elimination systems will bring a new …