… declaration of the ‘war on cancer’ by US President Nixon in 1971, researchers still face …
hurdles in cancer drug development and the number of drugs generally approved for oncology …

… cancer drug development, the US Orphan Drug Act incentivizes drug makers to repurpose
drugs … If an anticancer drug benefits pediatric populations, an additional 6 months may also be …

… immunotherapy is the original targeted therapy and includes any strategy that utilizes the
anticancer immune response or components of the immune system, as cancer treatment. …

… , cultural and funding problems for cancer drug discovery and development, together with …
The four key steps of cancer drug discovery that are covered in this review are highlighted …

… advancing drug development and improving medical treatments and how these hurdles can
… opened a promising era of cancer research and drug development. Unfortunately, many …

… the current limitations and future potential of gene therapy for the treatment of cancer. … major
restriction in treating cancer with gene therapy is the limitations in specifically targeting tumor …

… Finally, quality issues in biomarker development have been the subject of numerous … in
the drug development process, and ideally evaluated in the setting of new drug phase 1 trials. …

… cancer to become the largest public health problem worldwide. To face this challenge, improving
anticancer drug development … More efficacious anticancer drugs must reach patients in …

… To understand challenges in childhood cancer drug development better, … The next largest
funder is the NIH, which supports … The major hurdle is the lack of access to novel therapies for …

… the context of cancer therapy [6]. The marriage of nanotechnology and cancer treatment holds
the … However, navigating this promising terrain is not devoid of hurdles, encompassing the …