… This review focuses on major classes of anticancer drug targets and their therapeutic … new
potential drug targets. This has changed the paradigms of anticancer drug discovery toward …

… As such, the identification of specific drug targets in cancer cells that are synthetic lethal
in combination with mutant genes might allow the specific destruction of cancer cells while …

… of cancer has caused pharmacological interest to concentrate extensively on targeted
therapies as a more specific and effective way for blockade of cancer … activation of cancer-related …

… of agents in the third group to a consensus reference list on cancer driver genes 43 , we
observed only a small overlap between cancer drivers and current cancer drug targets. …

Ever since the discovery 20 years ago that the transforming retroviral v-sis oncogene is derived
from the platelet-derived growth factor (PDGF) B chain gene, PDGF signaling has been …

… cancer progression which is of critical importance to their utility as oncology drug targets, …
and functional activity of GPCRs in different types of cancer, along with the well-established ‘…

… of drug targets for multifactorial diseases such as cancer is … proteases as promising enzyme
targets in cancer. MMPs and … valid drug targets for patients with early- or late-stage cancer. …

… In this model, cancer is viewed as a multi-stage … targets of cancer drug development.
Given the complexity of Wnt/β-catenin signaling pathway, it is conceivable that potential cancer …

… targets exons encoding protein domains could be used to nominate individual domains as
cancer dependencies and potentially as drug targets… validated as therapeutic targets in MLL-…

Cancer cells are defined by their unlimited replicative potential and resistance to cell death
stimuli. It is generally considered that a point of no return in apoptotic cell death is the …