… that enable the survival of cancer cells during drug treatment and on current research
efforts to identify and overcome underlying mechanisms of resistance to both standard …

… Do we need to account for compensatory proliferation to explain the evolution of drug
resistance? Mathematical reasoning led to the conclusion that resistance mutations predate …

… ; the immune system and the microenvironment; undruggable cancer drivers; and the many
… solutions to drug resistance that are based on earlier detection of tumours permitting cancer …

… After examining the basic evolutionary dynamics of drug resistance in cancer, we turn to
a more applied question: How many drugs should be used to prevent treatment failure …

… In this review, intrinsic and acquired resistance will be discussed. In addition, new … of drug
resistance will be reviewed. Particularly, we will highlight roles of ATP in drug resistance by …

… Originally, tumours were believed to be composed of clonal populations of cancer cells at
any given stage of cancer evolution, with each new clonal population subsequently …

… model to evolution of resistance of cancer cells and discuss examples for diverse mechanisms
of resistance. … factor NF-κB induces drug resistance through MDR1 expression in cancer …

… within cancer cell populations, to account for drug resistance. To shed light on such
heterogeneity, we review evolutionary mechanisms that encompass the great evolution that has …

… evolutionary models of drug resistance in cancer mentioned above have assumed that the
tumor is spatially uniform. These works have investigated the temporal dynamics of evolution …

… In this review, we will examine studies that have monitored tumour evolution and … drug
resistance can frequently be attributed to the selection of pre-existing intrinsically resistant …